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CCK-A and CCK-B selective receptor agonists and antagonists modulate olfactory recognition in male rats

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Abstract

Modulation of learning and memory is one of the physiological roles that the neuropeptide cholecystokinin (CCK-8) may play. We have used a behavioural model of olfactory recognition among rats to test this hypothesis and to explore the relationship between CCK-A and CCK-B receptors and memory retention. Adult male rats form a transient memory of a juvenile congenere as indicated by a reduction in the duration of investigatory behaviour upon re-exposure 30 min after an initial exposure, but not when re-exposure is delayed until 120 min afterwards. In the present study, rats were treated after the first contact with various compounds; inhibition and facilitation of olfactory recognition were evaluated as the persistence in investigation 30 min and the decrease in investigation 120 min after pharmacological manipulations, respectively. Systemic injection of CCK-8, of a selective CCK-A agonist, or of non-peptide CCK-B antagonists (CI-988 and LY-262691) enhanced olfactory recognition. In contrast, the CCK-B selective agonist BC 264 and the tetrapeptide CCK-4 both disrupted it. Taken together with previous evidence of the detrimental effect of the non-peptide CCK-A antagonist devazepide on olfactory recognition, these results confirm and extend the hypothesis that there is a balance between CCK-A-mediated facilitative effects and CCK-B-mediated inhibitory effects on memory retention.

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Authors and Affiliations

  1. Département de Biologie, Rhône-Poulenc Rorer S.A., Centre de Recherches de Vitry-Alfortville, 13 quai Jules Guesde, F-94403, Vitry-sur-Seine Cedex, France

    M. Lemaire, G. A. Böhme, O. Piot & J. -C. Blanchard

  2. INSERM U266-CNRS UA498, Faculté de Pharmacie, F-75006, Paris, France

    B. P. Roques

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  1. M. Lemaire
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  2. G. A. Böhme
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  3. O. Piot
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  4. B. P. Roques
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  5. J. -C. Blanchard
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Lemaire, M., Böhme, G.A., Piot, O. et al. CCK-A and CCK-B selective receptor agonists and antagonists modulate olfactory recognition in male rats. Psychopharmacology 115, 435–440 (1994). https://doi.org/10.1007/BF02245565

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  • DOI: https://doi.org/10.1007/BF02245565

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