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Interference with eastern equine encephalomyelitis (EEE) virus in the brains of mice immune to lymphocytic choriomeningitis (LCM)

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Summary and Conclusions

EEE virus was titrated in the brains of mice infected or immunized with LCM virus and in normal controls. There was slight but definite interference in the former animals.

The interfering effect was about the same in tolerant mice infected congenitally with LCM virus, whose brains contain considerable amounts of active virus, as in non-tolerant mature animals infected experimentally, the great majority of which did not carry detectable quantities of LCM virus in their brains. The interference thus appeared to be independent of the amount of infectious LCM virus present in the central nervous system. It lasted longer in mature mice infected subcutaneously and challenged intracerebrally with LCM virus than in those inoculated subcutaneously only.

It has not been possible by the use of tissue culture methods to demonstrate an interferon in brains in which interference occurred. In spite of this negative result a substance of this kind appears to be involved.

The possible role of the interference phenomenon as an immunity factor in non-tolerant mice is discussed.

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Authors and Affiliations

  1. Bundesforschungsanstalt für Viruskrankheiten der Tiere in Tübingen a. N., Deutschland

    Erich Traub

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  1. Erich Traub
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The author is indebted to MissFriedel Kesting for efficient technical assistance.

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Traub, E. Interference with eastern equine encephalomyelitis (EEE) virus in the brains of mice immune to lymphocytic choriomeningitis (LCM). Archiv f Virusforschung 11, 419–427 (1961). https://doi.org/10.1007/BF01249595

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  • DOI: https://doi.org/10.1007/BF01249595

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