Skip to main content

Advertisement

Log in

The Importance of the Family: A Longitudinal Study of the Predictors of Depression in HIV Patients in South Africa

  • Original Paper
  • Published:
AIDS and Behavior Aims and scope Submit manuscript

Abstract

As a chronic illness, HIV/AIDS requires life-long treatment adherence and retention—and thus sufficient attention to the psychosocial dimensions of chronic disease care in order to produce favourable antiretroviral treatment (ART) outcomes in a sustainable manner. Given the high prevalence of depression in chronic HIV patients, there is a clear need for further research into the determinants of depression in this population. In order to comprehensively study the predictors of depressive symptoms in HIV patients on ART, the socio-ecological theory postulates to not only incorporate the dominant individual-level and the more recent community-level approaches, but also incorporate the intermediate, but crucial family-level approach. The present study aims to extend the current literature by simultaneously investigating the impact of a wide range individual-level, family-level and community-level determinants of depression in a sample of 435 patients enrolled in the Free State Province of South Africa public-sector ART program. Structural equation modeling is used to explore the relationships between both latent and manifest variables at two time points. Besides a number of individual-level correlates—namely education, internalized and external stigma, and avoidant and seeking social support coping styles—of depressive symptoms in HIV patients on ART, the study also revealed the important role of family functioning in predicting depression. While family attachment emerged as the only factor to continuously and negatively impact depression at both time points, the second dimension of family functioning, changeability, was the only factor to produce a negative cross-lagged effect on depression. The immediate and long-term impact of family functioning on depression draws attention to the role of family dynamics in the mental health of people living with HIV/AIDS. In addition to individual-level and community-based factors, future research activities should also incorporate the role of the family context in research into the mental health of HIV patients, as our results demonstrate that the familial context in which a person with HIV on ART resides is inextricably interconnected with his/her health outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. UNAIDS. Global report (UNAIDS report on the global AIDS epidemic 2013). Joint United Nations Programme on HIV/AIDS (UNAIDS). 2013.

  2. Motsoaledi A. Health budget vote speech by the Minister of Health Dr. Aaron Motsoaledi, MP. In: Health Do, editor. http://www.health-e.org.za/wp-content/uploads/2014/07/Minister-of-Health-Budget-Vote-Speech-2014-15-.pdf. 2014.

  3. Barth RE, Schim van der Loeff MF, Schuurman R, Hoepelman AIM, Wensing AMJ. Virological follow-up of adult patients in antiretroviral treatment programmes in sub-Saharan Africa: a systematic review. Lancet Infect Dis. 2010;10(3):155–66.

    Article  CAS  PubMed  Google Scholar 

  4. Wouters E, Heunis C, Michielsen J, Baron Van Loon F, Meulemans H. The long road to universal antiretroviral treatment coverage in South Africa. Future Virol. 2011;6(7):801–12.

    Article  Google Scholar 

  5. Johnson LF, Mossong J, Dorrington RE, Schomaker M, Hoffmann CJ, Keiser O, et al. Life expectancies of South African adults starting antiretroviral treatment: collaborative analysis of cohort studies. PLoS Med. 2013;10(4):e1001418.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Russell S, Seeley J. The transition to living with HIV as a chronic condition in rural Uganda: working to create order and control when on antiretroviral therapy. Soc Sci Med. 2010;70(3):375–82.

    Article  PubMed  Google Scholar 

  7. Wouters E, Van Damme W, Van Loon F, Van Rensburg D, Meulemans H. Public-sector ART in the FREE State Province, South Africa: community support as an important determinant of outcome. Soc Sci Med. 2009;69(8):1177–85.

    Article  PubMed  Google Scholar 

  8. Pence BW. The impact of mental health and traumatic life experiences on antiretroviral treatment outcomes for people living with HIV/AIDS. J Antimicrob Chemother. 2009.

  9. Collins PY, Holman AR, Freeman MC, Patel V. What is the relevance of mental health to HIV/AIDS care and treatment programs in developing countries? A systematic review. AIDS. 2006;20(12):1571–82.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Guaraldi G, Murri R, Orlando G, Squillace N, Stentarelli C, Zona S, et al. Lipodystrophy and quality of life of HIV-infected persons. AIDS Rev. 2008;10:152–61.

    PubMed  Google Scholar 

  11. Simbayi LC, Kalichman S, Strebel A, Cloete A, Henda N, Mqeketo A. Internalized stigma, discrimination, and depression among men and women living with HIV/AIDS in Cape Town, South Africa. Soc Sci Med. 2007;64(9):1823–31.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Nakimuli-Mpungu E, Bass J, Alexandre P, Mills E, Musisi S, Ram M, et al. Depression, alcohol use and adherence to antiretroviral therapy in Sub-Saharan Africa: a systematic review. AIDS Behav. 2012;16(8):2101–18.

    Article  PubMed  Google Scholar 

  13. Tomlinson M, Grimsrud AT, Stein DJ, Williams DR, Myer L. The epidemiology of major depression in South Africa: results from the South African stress and health study. SAMJ. S Afr Med J. 2009;99:368–73.

    Google Scholar 

  14. Ovuga E, Boardman J, Wasserman D. The prevalence of depression in two districts of Uganda. Soc Psychiatr Psychiatr Epidemiol. 2005;40(6):439–45.

    Article  Google Scholar 

  15. Wagner G, Goggin K, Remien R, Rosen M, Simoni J, Bangsberg D, et al. A closer look at depression and its relationship to HIV antiretroviral adherence. Ann Behav Med. 2011;42(3):352–60.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Gonzalez JS, Batchelder AW, Psaros C, Safren SA. Depression and HIV/AIDS treatment nonadherence: a review and meta-analysis. J Acquir immune Defic Syndr. 2011;58(2). doi:10.1097/QAI.0b013e31822d490a.

  17. Venkatesh KK, Flanigan TP, Mayer KH. Is expanded HIV treatment preventing new infections? Impact of antiretroviral therapy on sexual risk behaviors in the developing world. AIDS. 2011;25(16):1939–49.

    Article  PubMed  Google Scholar 

  18. Myer L, Smit J, Roux LL, Parker S, Stein DJ, Seedat S. Common mental disorders among HIV-infected individuals in South Africa: prevalence, predictors, and validation of brief psychiatric rating scales. Aids Patient Care STDS. 2008;22(2):147–58.

    Article  PubMed  Google Scholar 

  19. Pappin M, Wouters E, Booysen F. Anxiety and depression amongst patients enrolled in a public sector antiretroviral treatment programme in South Africa: a cross-sectional study. BMC Public Health. 2012;12(1):244.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Brandt R. The mental health of people living with HIV/AIDS in Africa: a systematic review. Afr J AIDS Res. 2009;8(2):123–33.

    Article  PubMed  Google Scholar 

  21. Yeji F, Klipstein-Grobusch K, Newell M-L, Hirschhorn LR, Hosegood V, Bärnighausen T. Are social support and HIV coping strategies associated with lower depression in adults on antiretroviral treatment? Evidence from rural KwaZulu-Natal, South Africa. AIDS Care. 2014;26(12):1482–9.

    Article  PubMed  Google Scholar 

  22. Nyirenda M, Chatterji S, Rochat T, Mutevedzi P, Newell M-L. Prevalence and correlates of depression among HIV-infected and -affected older people in rural South Africa. J Affect Disord. 2013;151:31–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Van Damme W, Kober K, Kegels G. Scaling-up antiretroviral treatment in Southern African countries with human resource shortage: how will health systems adapt? Soc Sci Med. 2008;66(10):2108–21.

    Article  PubMed  Google Scholar 

  24. Petersen I, Lund C. Mental health service delivery in South Africa from 2000 to 2010: one step forward, one step back. SAMJ. S Afr Med J. 2011;101:751–7.

    PubMed  Google Scholar 

  25. Petersen I, Bhana A, Baillie K. The feasibility of adapted group-based interpersonal therapy (IPT) for the treatment of depression by community health workers within the context of task shifting in South Africa. Community Ment Health J. 2012;48(3):336–41.

    Article  CAS  PubMed  Google Scholar 

  26. Petersen I, Lund C, Bhana A, Flisher AJ. The mental health poverty research programme consortium. A task shifting approach to primary mental health care for adults in South Africa: human resource requirements and costs for rural settings. Health Policy Plan 2012;27(1):42–51.

  27. Chibanda D, Mesu P, Kajawu L, Cowan F, Araya R, Abas M. Problem-solving therapy for depression and common mental disorders in Zimbabwe: piloting a task-shifting primary mental health care intervention in a population with a high prevalence of people living with HIV. BMC Public Health. 2011;11(1):828.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Masquillier C, Wouters E, Mortelmans D, le Roux Booysen F. The impact of community support initiatives on the stigma experienced by people living with HIV/AIDS in South Africa. AIDS Behav. 2015;19(2):214–26.

    Article  PubMed  Google Scholar 

  29. Wouters E. Mobilising the community in the fight against HIV/AIDS. Lancet. 2009;374(9693):1501.

    Article  PubMed  Google Scholar 

  30. Wouters E, Van Damme W, van Rensburg D, Masquillier C, Meulemans H. Impact of community-based support services on antiretroviral treatment programme delivery and outcomes in resource-limited countries: a synthetic review. BMC Health Services Res. 2012;12(1):194.

    Article  Google Scholar 

  31. Pfeiffer PN, Heisler M, Piette JD, Rogers MAM, Valenstein M. Efficacy of peer support interventions for depression: a meta-analysis. Gen Hosp Psychiatr. 2011;33(1):29–36.

    Article  Google Scholar 

  32. World Health Organisation (WHO). Treat, train, retain. Task shifting. Global recommendations and guidelines. Geneva: WHO, PEPFAR & UNAIDS. 2008.

  33. Yaw Amoateng A. Towards a conceptual framework for families and households. In: Yaw Amoateng A, Heaton TB, editors. Families and households in post-apartheid South Africa: socio-demographic perspectives. HSRC Press, Cape Town, South Africa; 2007, p. 27–42.

  34. Wouters E. Life with HIV as a chronic illness: a theoretical and methodological framework for antiretroviral treatment studies in resource-limited settings. Soc Theory Health. 2012;10(4):368–91.

    Article  Google Scholar 

  35. Chandra PS, Ravi V, Desai A, Subbakrishna DK. Anxiety and depression among hiv-infected heterosexuals—a report from india. J Psychosom Res. 1998;45(5):401–9.

    Article  CAS  PubMed  Google Scholar 

  36. Dyer T, Stein J, Rice E, Rotheram-Borus M. Predicting depression in mothers with and without HIV: the role of social support and family dynamics. AIDS Behav 2012:1–11.

  37. Rotheram-Borus M, Stein J, Jiraphongsa C, Khumtong S, Lee S-J, Li L. Benefits of family and social relationships for Thai parents living with HIV. Prev Sci. 2010;11(3):298–307.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Olley BO, Seedat S, Nei DG, Stein DJ. Predictors of major depression in recently diagnosed patients with HIV/AIDS in South Africa. Aids Patient Care STDS. 2004;18(8):481–7.

    Article  CAS  PubMed  Google Scholar 

  39. Wolitski R, Pals S, Kidder D, Courtenay-Quirk C, Holtgrave D. The effects of HIV stigma on health, disclosure of HIV status, and risk behavior of homeless and unstably housed persons living with HIV. AIDS Behav. 2009;13(6):1222–32.

    Article  PubMed  Google Scholar 

  40. Wright K, Naar-King S, Lam P, Templin T, Frey M. Stigma scale revised: reliability and validity of a brief measure of stigma for HIV + youth. J Adolesc Health. 2007;40(1):96–8.

    Article  PubMed  Google Scholar 

  41. Fleishman J, Fogel B. Coping and depressive symptoms among young people with AIDS. Health Psychol. 1994;13(2):156–69.

    Article  CAS  PubMed  Google Scholar 

  42. Smith PN. Resilience in Xhosa families. Stellenbosch: University of Stellenbosch; 2006.

    Google Scholar 

  43. Niehof A. Conceptualizing the household as an object of study. Int J Consum Stud. 2011;35(5):488–97.

    Article  Google Scholar 

  44. Randall S, Coast E, Leone T. Cultural constructions of the concept of household in sample surveys. Popul Stud. 2011;65(2):217–29.

    Article  Google Scholar 

  45. Black K, Lobo M. A conceptual review of family resilience factors. J Fam Nurs. 2008;14(1):33–55.

    Article  PubMed  Google Scholar 

  46. McCubbin MA, McCubbin HI. Resiliency in families: A conceptual model of family adjustment in response to stress and crises. In: McCubbin HI, Thompson AI, McCubbin MA, editors. Family assessment: resiliency, coping and adaptation—inventories for research and practice. Madison: University of Wisconsin-Madison; 1996. p. 1–64.

    Google Scholar 

  47. McCubbin HI, Thompson AI, Elver KM. Family attachment and changeability index 8 (FACI 8). In: McCubbin HI, Thompson AI, McCubbin MA, editors. Family assessment resiliency, coping and adaptation-inventories for research and practice. Madison University Wisconsin System; 1996. p. 725–51.

  48. Wouters E, Masquillier C, Ponnet K, le Roux Booysen F. A peer adherence support intervention to improve the antiretroviral treatment outcomes of HIV patients in South Africa: the moderating role of family dynamics. Soc Sci Med. 2014;113:145–53.

    Article  PubMed  Google Scholar 

  49. Braveman PA, Cubbin C, Egerter S, et al. Socioeconomic status in health research: one size does not fit all. JAMA. 2005;294(22):2879–88.

    Article  CAS  PubMed  Google Scholar 

  50. Chandola T, Bartley M, Wiggins R, Schofield P. Social inequalities in health by individual and household measures of social position in a cohort of healthy people. J Epidemiol Community Health. 2003;57(1):56–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Freeman M, Nkomo N, Kafaar Z, Kelly K. Factors associated with prevalence of mental disorder in people living with HIV/AIDS in South Africa. AIDS Care. 2007;19(10):1201–9.

    Article  CAS  PubMed  Google Scholar 

  52. Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the hospital anxiety and depression scale: an updated literature review. J Psychosom Res. 2002;52(2):69–77.

    Article  PubMed  Google Scholar 

  53. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.

    Article  CAS  PubMed  Google Scholar 

  54. Chandra PS, Deepthivarma S, Jairam KR, Thomas T. Relationship of psychological morbidity and quality of life to illness-related disclosure among HIV-infected persons. J Psychosom Res. 2003;54:199–203.

    Article  PubMed  Google Scholar 

  55. Snaith RP. The hospital anxiety and depression scale. Health Quality Life Outcomes. 2003;1(1):29.

    Article  Google Scholar 

  56. Wouters E, Booysen FIR, Ponnet K, Baron Van Loon F. Wording effects and the factor structure of the hospital anxiety & depression scale in HIV/AIDS patients on antiretroviral treatment in South Africa. PLoS ONE. 2012;7(4):e34881.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Hu L-t, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Struct Equ Model Multidiscip J. 1999;6(1):1–55.

    Article  Google Scholar 

  58. Muthen L, Muthen B. Chi square difference testing using the S-B scaled Chi square. Note on Mplus website. 2005.

  59. van de Schoot R, Lugtig P, Hox J. A checklist for testing measurement invariance. Eur J Dev Psychol. 2012;9(4):486–92.

    Article  Google Scholar 

  60. Burkholder GJ, Harlow LL. An illustration of a longitudinal cross-lagged design for larger structural equation models. Struct Equ Model Multidiscip J. 2003;10(3):465–86.

    Article  Google Scholar 

  61. Adewuya AO, Afolabi MO, Ola BA, Ogundele OA, Ajibare AO, Oladipo BF, et al. Relationship between depression and quality of life in persons with HIV infection in Nigeria. Int J Psychiatr Med. 2008;38(1):43–51.

    Article  Google Scholar 

  62. Kaharuza F, Bunnell R, Moss S, Purcell D, Bikaako-Kajura W, Wamai N, et al. Depression and CD4 cell count among persons with HIV infection in uganda. AIDS Behav. 2006;10(1):105–11.

    Article  Google Scholar 

  63. Carrico A, Antoni M, Durán R, Ironson G, Penedo F, Fletcher M, et al. Reductions in depressed mood and denial coping during cognitive behavioral stress management with hiv-positive gay men treated with haart. Ann Behav Med. 2006;31(2):155–64.

    Article  PubMed  Google Scholar 

  64. Kim J, Jeong Yeob Han H, Shaw B, McTavish F, Gustafson D. The roles of social support and coping strategies in predicting breast cancer patients’ emotional well-being: testing mediation and moderation models. J Health Psychol. 2010;15(4):543–52.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Savard J, Laberge B, Gauthier JG, Ivers H, Bergeron MG. Evaluating anxiety and depression in HIV-infected patients. J Pers Assess. 1998;71(3):349–67.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Edwin Wouters.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wouters, E., Masquillier, C. & le Roux Booysen, F. The Importance of the Family: A Longitudinal Study of the Predictors of Depression in HIV Patients in South Africa. AIDS Behav 20, 1591–1602 (2016). https://doi.org/10.1007/s10461-016-1294-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10461-016-1294-0

Keywords

Navigation