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Cardiac Natriuretic Hormones as Markers of Cardiovascular Disease: Methodological Aspects

  • Chapter
Natriuretic Peptides

Abstract

Cardiac natriuretic hormones (CNH) constitute a complex family of related peptides with similar peptide chains as well as degradation pathways (see Chap. 3 for more details). CNH derive from common precursors, pre-pro-hormones (i.e., preproANP and preproBNP). Pro-hormone peptides are further split into an inactive longer NT-proANP or NTproBNP and the biologically active hormones, ANP or BNP, which are secreted in the blood in equimolar amounts. However, ANP and BNP have a shorter plasma half-life and consequently lower plasma concentrations compared to NT-proANP and NT-proBNP (Table 4.1). For these reasons, setting up an immunoassay for N-terminal peptide fragments of proANP and proBNP should be easier than that for ANP and BNP, because the requested analytical sensitivity is not too low [1]. However, immunoassays for NTproANP and NTproBNP may be affected by problems related to the different assay specificities: as shown in Table 4.1, different results are produced by different methods with a large bias [1–3]. The different analytical performances could have some relevance in the diagnostic accuracy of different assay methods in discriminating between subjects with or without cardiac disease [1–11].

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Authors and Affiliations

  1. Medical School, University of Milan, Italy

    Mauro Panteghini MD (Full Professor of Clinical Biochemistry and Clinical Molecular Biology and Director of the corresponding chair)

  2. Laboratory of Cardiovascular Endocrinology and Cell Biology, CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Italy

    Aldo Clerico MD (Director)

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  1. Mauro Panteghini MD
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  2. Aldo Clerico MD
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Editors and Affiliations

  1. Department of Laboratory Medicine Institute of Clinical Physiology, CNR - National Research Council, Pisa, Italy

    Aldo Clerico  & Michele Emdin  & 

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Panteghini, M., Clerico, A. (2006). Cardiac Natriuretic Hormones as Markers of Cardiovascular Disease: Methodological Aspects. In: Clerico, A., Emdin, M. (eds) Natriuretic Peptides. Springer, Milano. https://doi.org/10.1007/88-470-0498-5_4

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  • DOI: https://doi.org/10.1007/88-470-0498-5_4

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