Evaluation of Hypoglycaemic, Antihyperglycaemic and Anti-lipid Peroxidative Activity of Persea americana Peel in Wistar Rats

O. N. Ilochi *

Department of Human Physiology, Faculty of Basic Medical Sciences, Madonna University, Elele, Rivers State, Nigeria.

T. A. Kolawole

Department of Human Physiology, PAMO University of Medical Sciences, Port Harcourt, Rivers State, Nigeria.

A. N. Chuemere

Department of Human Physiology, Faculty of Basic Medical Sciences, Madonna University, Elele, Rivers State, Nigeria and Department of Human Physiology, Faculty of Basic Medical Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria and Department of Nursing, Faculty of Basic Medical Sciences, Clifford University, Owerrinta, Abia State, Nigeria.

*Author to whom correspondence should be addressed.


Abstract

This study evaluated the hypoglycaemic, antihyperglycaemic and anti-lipid peroxidative  activity of Persea americana peel in experimental rats. 60 male wistar rats were used for this study which lasted for 42 days. The animals were randomly grouped as: A-Normal control (feed + distilled water), B- Glibenclamide 0.6mg/kg/day, C- Avocado peel extract 50mg/kg, D- Diabetic, E- Diabetic + glibenclamide 0.6mg/kg/day, F- Diabetic + avocado peel extract 50mg/kg.  Fasting blood glucose and blood level of glycated hemoglobin (HbA1C) were assayed for. With standard protocols, the heart and kidney of each animal was collected for tissue homogenization. Biochemical analysis of tissue homogenates includes Thiobarbituric acid reactive substances (TBARS) and isoprostanes (F2isoP). This study revealed a possible link between oxidative stress and hyperglycaemia in diabetic conditions. Avocado peel, dose and time-dependently reduced blood glucose level below normal as well as products of lipid peroxidation. Determination of the possible mechanisms by which avocado peel affects these biomarkers may be indispensible to medicinal research. This study revealed further therapeutic potential of avocado peel.

Keywords: Diabetic, persea americana, endemic, peel, analysis


How to Cite

Ilochi, O. N., Kolawole, T. A., & Chuemere, A. N. (2022). Evaluation of Hypoglycaemic, Antihyperglycaemic and Anti-lipid Peroxidative Activity of Persea americana Peel in Wistar Rats. Journal of Advances in Medicine and Medical Research, 34(6), 78–83. https://doi.org/10.9734/jammr/2022/v34i631316

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