A 47-year-old female of alcoholic neuropathy was reported. She showed sensorimotor disturbance with glove and stocking type distribution. Electromyography demonstrated signs of denervation, and nerve conduction velocities were slightly decreased in the lower limbs. Quantitative histologic and ultrastructual studies were performed in the sural nerve biopsied. In the teased fiber analysis myelinated fibers showing axonal degeneration was observed in 36% and segmental demyelination in 12%. Determinations of fiber densities revealed a remarkable decrease of the density of large myelinated fibers with normal density of small myelinated and unmyelinated fibers. The clinical, electrophy-siological and histrometric findings of this case is similar to those of cases of beriberi neuropathy.