Evaluation of knowledge and barriers of influenza vaccine uptake among university students in Saudi Arabia; a cross-sectional analysis

Background Influenza vaccine hesitancy is a significant threat to global maneuvers for reducing the burden of seasonal and pandemic influenza. This study estimated the vaccine uptake, barriers, and willingness for influenza vaccines among university students in Saudi Arabia. Methods A cross-sectional survey was conducted among health science (HS) and non-health science (NHS) university students. A 31-item questionnaire was used to ascertain the vaccination rate, barriers, and willingness for the flu vaccine. Results This study included 790 students (mean age: 21.40 ± 1.94 years), 246 (31.1%) from HS and 544 (68.9%) from NHS disciplines. About 70% did not take flu shots before the arrival of the winter. The mean knowledge score was 7.81 ± 1.96, where 20.4%, 67.6%, and 12% of respondents had good, moderate, and poor knowledge regarding flu vaccines. The relative importance index (RII) analysis showed a lack of recommendation from physicians (51.5%, RI ranked: 1) was a top-ranked barrier to vaccine uptake, followed by negative perceptions and accessibility issues. Only 36.6% of the participants were willing to get vaccinated every year, 70% were willing to receive a vaccine on their doctor’s recommendations, and 46% agreed to vaccinate if vaccines were freely available in the university. The knowledge, barriers, and willingness widely varied across students from two disciplines. Conclusions Our analysis underscored low flu vaccine uptake among university students. In addition, the study participants’ knowledge was unsatisfactory, and they were less inclined to receive the flu vaccine in the future. Lack of recommendation from the physicians, negative perceptions towards the flu vaccine, and difficult accessibility were found as significant barriers to the vaccine uptake. A multidimensional approach at educational institutes to cover the knowledge gap and address the barriers curtailing the vaccination rate among students is recommended.


INTRODUCTION
The influenza virus is responsible for a contagious and acute respiratory infection commonly known as seasonal flu or influenza, contributing substantially to the global disease burden (WHO, 2019a). Seasonal influenza can cause illness of mild to even fatal nature manifested by fever, dry cough, headache, muscular pain, malaise, and joint pain (Hayward et al., 2014). The World Health Organization (WHO) in 2017 reported 250,000 to 500,000 death toll across the globe due to influenza (GBD 2017Influenza Collaborators, 2019. These estimates were revisited by Paget et al. (2019), in 2019, with an average of 389,000 deaths per annum. However, flu vaccine receipt reduces the risk of contracting the infection and the associated morbidity and mortality (Buchman et al., 2021). WHO recommends influenza vaccine uptake on an annual basis due to continuous genomic changes in the influenza virus (WHO, 2019a;Rodríguez-Blanco & Tuells, 2019;Kim, Webster & Webby, 2018).
Despite the recommendation, the rate of flu vaccine uptake, unfortunately, remains lower in various regions around the globe, i.e., in UAE: 24.7%, Southern California: 43%, and Australia: 53.8%, particularly 9.1% in Saudi Arabia (Abu-Gharbieh et al., 2010;Rogers, Bahr & Benjamin, 2018;Salem et al., 2019;Oakley et al., 2021). Various investigations from Saudi Arabia reported vaccine uptake rates of 48% to 58% in medical students and 41% in health care workers (Milunic et al., 2010;Ali et al., 2007;Lee et al., 2012;Al-Tawfiq, 2012). Vaccine hesitancy is a major challenge in vaccine receipt and one of the top ten threats to global health (WHO, 2019b). WHO defines vaccine hesitancy as the refusal or delay in acceptance of vaccines regardless of the availability of vaccination services (MacDonald, 2015). Additionally, some well-documented barriers to vaccine uptake include unavailability, inaccessibility, lack of motivation and knowledge regarding the benefits of the flu shot. These aforementioned barriers keep the vaccine coverage below WHO recommendation, i.e., 90% (Lee et al., 2012;Nichol, D'Heilly & Ehlinger, 2008;Bednarczyk et al., 2015;Merrill et al., 2010). Some additional barriers influencing the willingness include affordability, inaccessibility, inconvenience, false perception, lack of knowledge, and awareness (Choucair et al., 2021;Ryan et al., 2019;Alhawsawi et al., 2020;Silva, Bratberg & Lemay, 2021). However, due to reportedly rising outbreaks of different types of seasonal flu in Saudi Arabia, a proactive understanding of barriers and motivators of vaccine uptake by the university students is of paramount importance to curb the growing encumbrance of vaccine-preventable diseases (VPDs) (WHO, 2019b;Balkhy et al., 2004).
Previously conducted studies in Saudi Arabia included healthcare workers (HCWs), parents, and medical students' population (Alkathlan et al., 2020;Alshammari et al., 2014). However, there has been a shift in decision-making trends from parents to students over the years. Additionally, students have an increased potential for contracting the infection due to close proximity, living in crowded dorms, continuous social interaction at the workplace and social events, and more potential to transmit while returning home. In general, there is a knowledge gap between health and non-health sciences students. Medical students have a better understanding of disease and are more likely to receive vaccines than non-medical students. Moreover, healthcare students are considered future healthcare professionals, and WHO also has priorities in the vaccine campaign on healthcare workers, along with elderly people and pregnant women (Hayward et al., 2014;Hamdan et al., 2021). However, non-health students are the larger subset of the student community.
On the contrary, there is a dearth of investigations ascertaining the perception of non-medical students towards influenza vaccination. We intended this study to gather data on the flu vaccine uptake rate and to ascertain and compare the barriers to the uptake of flu shot among the non-health sciences students and healthcare students of Jouf, Saudi Arabia. In addition, evaluating knowledge and perception regarding influenza vaccine among the two groups of students will aid the health authorities to design and implement vaccination campaigns in educational institutes. To the best of our knowledge, this study is novel in that aspect we included students from both health and non-health disciplines.

Ethical statement
Ethical approval was obtained from the Institutional Committee of Bioethics (Reference no.: 06-05-43). The participation in this study was on a volunteer basis and written informed consent was obtained from each participant. A brief description of the study and its purpose was also provided at the beginning of the study. The anonymity of the respondents was ensured before analysis.

Study site and design
This web-based cross-sectional study was conducted among students from Jouf University, Saudi Arabia. Inclusion criteria for recruitment into the present study were: (1) All the students enrolled in the university, regardless of their discipline and year of study, (2) willing to participate, (3) age 18 years and above, (4) either male or female, and (5) were able to write and read Arabic or English. All the respondents not fulfilling the inclusion criteria were excluded from the study. The methodological flow chart of the current study is described in Fig. 1.

Study duration
Data was collected over five months period, starting from February to June 2021.

Sample size and sampling technique
The minimum sample size was estimated using the Cochran formula for sub-groups in a population: n = 2Z 2 pq d 2 . Where, n = desired sample size, Z = level of confidence according to standard normal deviation (1.96 corresponding to 95% confidence interval), p = proportion in the target population having a particular characteristic, q = proportion in the target population not having particular characteristics, i.e., 1-p, and d = degree of accuracy required (0.05). The minimum population size was adjusted for non-response and drop-out of 25% with the power of 0.80, resulting in a required sample size of 424.

Study instrument
A 31-items questionnaire was developed after reviewing previous literature (Rogers, Bahr & Benjamin, 2018;Benjamin & Bahr, 2016). The panel of experts reviewed the study instrument for the content and face validity, and their recommendations were considered in the finalized questionnaire. The validity of the questionnaire was determined by piloting a sample of 30 students to ascertain if the questions were valid and understandable. This data from the pilot study was not included in the final results. The reliability of the questionnaire was assessed by a Cronbach alpha value (0.77), which indicated the adequacy of the survey tool. The study instrument comprised of four sections: 1. Section I had questions related to demographics, including age, gender, marital status, the field of education, and questions related to flu vaccination status. 2. Section II consisted of thirteen true and false statements related to the knowledge of students about the flu vaccine. These items were 1 for ''correct'' answers and 0 for ''wrong'' and ''don't know'' responses. The maximum cumulative knowledge score was 13. The knowledge score was further categorised into three levels, i.e., poor knowledge (score ≤ 5), moderate knowledge (score 6 to 9), and good knowledge (score ≥ 10) (Salman et al., 2020;Srichan et al., 2020). Section III consisted of questions identifying the barriers influencing the receipt of the flu vaccine. Eleven barriers in this study were broadly classified under five categories. These five categories of barriers included affordability (1 item), accessibility (2 items), negative perception (5), lack of recommendation (1 item), and religious and cultural restrictions (2 items). All the responses were collected on a 5-point Likert scale (''Agree'', ''Strongly agree'', ''Neutral'', ''Disagree'', to ''Strongly disagree''). Responses were collapsed for further analysis by re-coding the values for strongly agree and agree as '1''; the values for disagree, strongly disagree, and neutral as '0''. The maximum barrier score was 11. Percentage agreement was calculated for the participants who agreed to the statements. Statements portraying the perceptions and barriers were ranked to determine the significant barriers associated with vaccine uptake (Bali et al., 2013;Eppes et al., 2013). Moreover, negative perceptions were specifically assessed in relation to vaccine uptake. 3. Section IV consisted of statements regarding the willingness of the students to take the flu shots. Willingness was determined using a set of seven questions with a response of ''Yes'', ''No'' and ''Don't know''. These responses were re-coded and dichotomized, i.e., 1 for agreeing to the statement and 0 for ''disagree'' and ''don't know'' responses. The maximum willingness score was 7. The level of willingness was stratified into three levels: poor level (≤ 2 score), moderate level (3-5 score), and good level (≥ 6 score) of willingness to receive flu vaccine (Srichan et al., 2020;Eppes et al., 2013).

Data collection
Convenient sampling was used and all the students were invited via electronic mail.
Students' e-mail addresses were obtained from the university database. Researchers approached the students via e-mails, with a link to the questionnaire enclosed with it. They explained the purpose of the survey, keeping the anonymity and confidentiality of the respondents. Incomplete responses were excluded from further analysis. The data collected online was scrutinised and converted to an excel sheet. Only completed responses were considered and subjected to further analysis. Survey responses were kept anonymous and were only accessible to the researchers.

Operational definitions
Vaccinated participants were referred to those ''who took the flu shot before the arrival of the winter season'' and non-vaccinated were ''those who did not receive it before winter''. Participants' knowledge was stratified into three levels: Good, moderate, and low knowledge referred to knowledge score ≥10, 6-9, and ≤ 5, respectively. Barriers mean factors hindering vaccine uptake. Perception refers to participants' beliefs regarding the vaccine uptake, whereas negative perception refers to the negative thinking of participants about the vaccine. The perception score is referred to as ''the mean cumulative perception score''. Percentage agreement is ''the % of participants who agreed to the statement or item of the study toll''. The participant was considered concerned if he/she agrees with the negative perception: extremely concerned, quite concerned, and little concerned. Vaccine acceptors referred to the ''participants who agreed to take the vaccine every year''. Vaccine hesitant referred to the ''participants who disagreed to take the flu vaccine every year''. Vaccine ambivalent referred to the ''participants who were not sure to receive the flu vaccine every year''.

Data analysis
Data analysis was done using SPSS version 21. Shapiro-Wilk and Kolmogorov-Smirnoff tests were used to evaluate the distribution of the data obtained from the survey. Continuous data were expressed as mean (±SD), while categorical data were summarised as frequency (%). Categorical data were compared using the Chi-square test or the Fisher exact test, where appropriate. The relative importance index (RII) was used to determine the pertinence of the statements, identifying and ranking the barriers to vaccine uptake. The value of RII ranges from 0 to 1; the value closest to 1 corresponds to the highest rank and main barrier. RII equation: Where, N is the total number of participants, A is the highest weight, and W is the weight given to each statement by the participant (1: strongly disagreed to 5: strongly agreed). Furthermore, percentage agreement was calculated to evaluate the % of people who agree with the statement. To evaluate the % agreement to the negative perception statements, the 5-point Likert scale was collapsed to two points i.e., ''agree'' and ''disagree''. Mean knowledge and perception score were compared between the two groups using an independent t -test. Association between demographic variables, knowledge, perception, and willingness with vaccine uptake were evaluated using Pearson correlation, simple linear regression, or chi-square, where appropriate. Multivariate analysis using a logistic regression model was run to determine the association between the independent demographic variables with the flu vaccine uptake. The variables having a statistically significant value of 0.05 were included in the bivariate analysis. These predictive variables that showed significant association (p-value <0.05) on bivariate analysis were further included in a multivariable logistic regression model. Variables included in the model were age, gender, marital status, the field of education, knowledge, perception, and willingness. A 95% confidence interval (CI) was calculated to reveal the odds ratio (OR). P-value of <0.005 was considered statistically significant.

Characteristics of study participants
Of the total 790 participants, 246 (31.1%) belonged to health sciences, and 544 (68.9%) were from non-health science disciplines. The mean age of participants was 21.40 ± 1.94 years, and most (83.9%) were single. There was an almost equal distribution of males (401, 50.8%) and females (389, 49.2%) gender. Table 1 summarises the demographic characteristics of the study participants.

Vaccination rate among study participants
The majority of the participants (n = 549, 69.5%) did not receive a flu shot before the winter season. There was a significant difference among the health sciences (HS) and non-health sciences (NHS) group w.r.t receipt of flu jab (flu shot before joining university: (HS:58.9% vs. NHS:35.5%; p < 0.001); and before arrival of the winter: (HS:38.6% vs. NHS:26.8%; p = 0.001)).

Knowledge regarding influenza vaccination
One-third (67.6%) of study participants had moderate knowledge about the influenza vaccination with a mean knowledge score of 7.81 ± 1.96, differing significantly among the HS and NHS group (p < 0.001). Surprisingly, only 20.4% of students indicated good knowledge, with a majority being from the HS group (n = 88, 54.7%) ( Table 2). Furthermore, high knowledge score was associated with gender (p-value < 0.001), field of education (p-value < 0.001), and year of education (p-value < 0.001). The knowledge score significantly differed across vaccinated and non-vaccinated participants (p-value 0.015; F = 3.152). Interestingly, females scored higher than males (8.48 ± 1.81 vs. 7.17 ± 1.88; p < 0.001). Item-wise analysis showed that most of the participants correctly responded that vaccines should be given to all persons aged six months and greater (n = 605, 76.6%), the vaccine reduces the severity and duration of flu (n = 576, 72.9%), and improves the immunity (n = 575, 72.8%).

Barriers to receiving flu vaccine
Our analysis compared 11 potential barriers to flu vaccine uptake (Table 3). Of these, ''lack of recommendation by the doctor'' was the highest-ranked (RI: 0.775), reported by 281 (51.5%) participants. The self-limiting nature of flu was ranked second (RI: 0.762), where 49.4% of participants responded that ''flu is seasonal and will recover on its own''. Approximately half of the participants (50.3%) agreed with the statement ''I believe that flu vaccine causes flu and fever'' and ranked third (RI: 0.760). However, the lowest-ranked barrier was ''vaccines are expensive,'' and only 11.5% of participants agreed with it. Moreover, negative perceptions among participants were specifically assessed for their relationship with the vaccine uptake. The mean negative perception score was higher in those who did not receive the vaccine (5.17 ± 2.11; 68.5%).

Willingness to receive influenza vaccine
The mean willingness score among study participants was 3.54 ± 1.57 (Table 4). About one-third (n = 289, 36.6%) of study participants were willing to get vaccinated every year. However, the majority of the respondents (n = 545, 69%) were willing to receive the flu shot on their doctor's recommendations, and 46.1% agreed to get the vaccine if provided free of cost at the university. The vaccine is available in intramuscular injection and intra-nasal

Notes.
Only agreed responses were included. a % Agreement: Percentage of participants who agreed to the statement (score of 4-5). b Relative index. c Barriers and perceptions to influenza vaccine uptake were ranked as per RII. spray dosage forms in various parts of the world. However, only the intramuscular route of the flu vaccine is available in Saudi Arabia. Surprisingly, most students (n = 496, 62.8%) were inclined to get a flu vaccination via intramuscular route compared to intra-nasal spray (n = 201, 25.4%). Willingness status was further stratified as vaccine acceptor (n = 289, 36.6%), vaccine rejecter (n = 131, 16.6%), and vaccine ambivalent (n = 370, 46.8%). Moreover, the majority (n = 277, 77.6%) of the non-vaccinated participants reported a poor level of willingness. However, half of the study population (n = 390, 49.4%) had a moderate level of willingness to receive the flu vaccine. There was a positive correlation (0.001*) between the knowledge and willingness score for the flu vaccine.

Determinants of influenza vaccine uptake
In Table 5, the majority of the population (n = 549, 69.5%) did not take the vaccine shot before winter. In binary analysis, age (22-25 years: OR: 0.730, p = 0.044), study field (non-health sciences: OR: 1.715, p = 0.001), poor knowledge score (OR: 2.021, p = 0.010), and poor willingness level (OR: 2.049, p <0.001) were found to be associated with reduced vaccine uptake. Adjusted regression analysis also identified similar factors associated with the reduced vaccine uptake.

DISCUSSION
The educational institutes are required to provide the primary platform to their students to avail all necessary health awareness in addition to academics. Since the students contribute a large proportion of the country's population, their participation in vaccination campaigns is an impetus to achieve herd immunity against vaccine-preventable diseases. To the best of our knowledge, this is the first cross-sectional analysis evaluating the flu vaccination rate, knowledge, and barriers among health-sciences and non-health-sciences students from a Saudi University. Despite the recommendation of the annual vaccine against influenza, the vaccine uptake rate remains considerably low, especially among students. Generally, students consider themselves healthy individuals who are less likely to contract the infection and have a low vaccination rate. This survey reported that only one-third of the students were vaccinated before the arrival of the winter season. These results corroborate the findings of other studies (Choucair et al., 2021;Benjamin & Bahr, 2016;Endrich, Blank & Szucs, 2009;Blank, Schwenkglenks & Szucs, 2009). However, these findings are evidently lower than the previously conducted studies in Saudi Arabia (Rogers, Bahr & Benjamin, 2018;Alkathlan et al., 2020;Alshammari et al., 2014), which might be possible due to a wide disparity in study population and methodology.
Only 20.4% of students demonstrated good knowledge regarding flu vaccination and knowledge score was comparatively better among HS students (88, 54.7%). However, it is worth mentioning that a large proportion of HS students recorded incorrect responses for some items. Since influenza vaccines are quadrivalent and provide protection against four viral strains, 30.1% of HS students responded that the influenza vaccine provides coverage against all flu-causing viral strains. Though vaccinated participants and those from HS disciplines demonstrated better knowledge, educational interventions must be initiated regardless of the study disciplines and vaccination status. Unsatisfactory vaccination rates and poor knowledge have also been reported in another study from Saudi Arabia (Alhawsawi et al., 2020).
This study identified 11 barriers to vaccine uptake among students, including five negative perceptions of the flu vaccine. These barriers might be addressed through awareness and educational campaigns at the university level. The proportion of these barriers was more profound among non-vaccinated students. They have concerns about vaccine efficacy, safety, and side effects, and these findings are consistent with the previous studies (Woolf, Chapman & Lee, 2021;Taylor et al., 2020;Fisher et al., 2020;Ali et al., 2018;Ru-Chien & Neuzil, 2004). We have classified the barriers into five broad categories including affordability, accessibility, negative perceptions, lack of recommendation, and cultural or religious restrictions. The lack of recommendation from the healthcare professionals was found as a top-ranked barrier to flu vaccination. These results necessitate the need for target interventions on health professionals so they could guide their patients on the importance of flu vaccines. Moreover, arranging the health screening camps at the university level will aid to overcome these barriers and improve the vaccination rates among students. The lack of recommendations for flu vaccines from healthcare professionals has also been reported in other studies (Bovier et al., 2001). It is important to note that 69% of participants agreed to get the flu shots if their physicians would make such recommendations. This could be turned into an effective facilitator, improving the overall vaccination status. The importance of this facilitator has also been discussed in another study (Ru-Chien & Neuzil, 2004). Educating the population about the significance of the influenza vaccine directly influences the willingness of the individuals to get vaccinated (Bednarczyk et al., 2015). Awareness campaigns can be arranged at the institutional level, via media, and through other online resources. Educational activities also need to address the negative perceptions, misleading narratives, and myths prevailing among students. Awareness of the students will positively influence the decision-making skills of the emerging adult population.
Approximately, one-third (36.6%) of the study population were willing to get the flu vaccine every year. However, this proportion increased to 46.1% if the flu vaccines would be provided free of cost on-campus. Two-thirds of the participants were willing to get the flu shot if it is recommended by their doctors. The low vaccination rate in this study is also associated with a lack of awareness about the whereabouts of the vaccination centers, as one-fourth of the study population reported that they do not know where to get the flu shots. An explanation for this association could be that those who knew where to get their flu shot were most likely to get vaccinated. In addition, non-vaccinated participants were more willing to receive the flu vaccine in the future. On the other hand, vaccinated participants demonstrated a lesser intention to take the vaccine again. The accessibility of the vaccine is a pivotal facilitator in achieving a high vaccination rate. Considering the poor health-seeking behaviour of the students, accessibility of the vaccines in the universities at the micro-level will aid to improve the vaccine uptake in this population. Lower vaccine hesitancy was reported (16.6%) as compared to a study conducted by Alzeer et al. (2021), which reported 42% vaccine hesitancy among the participants.
The increased age, study discipline, poor knowledge, and willingness for vaccines were found to be associated with reduced vaccine uptake. This study did not demonstrate any association between knowledge and willingness to receive the vaccine (p = 0.349). The results of previous investigations showed that only good knowledge is not enough to encourage vaccine uptake and attitudes about the value and risk, as well as negative perceptions also negate the decision of getting influenza vaccine (Black et al., 2015;O'Reilly, Cran & Stevens, 2005;Romine, Barrow & Folk, 2013;Martinello, Jones & Topal, 2003).
Students who were vaccinated and from healthcare disciplines had higher knowledge of vaccine uptake which might be attributed to their attitude towards the importance of vaccination. In addition, females demonstrated higher knowledge as compared to males. Since students having high knowledge scores are more likely to receive the flu vaccination, this hypothesis was further tested. Our analysis showed that poor knowledge and willingness were associated with reduced vaccine uptake. In addition to the demographics, there is a dire need to evaluate some other factors influencing the decision-making behaviour of students for vaccination such as myths and anti-vaxxers campaigns on social media. The improvement of the knowledge is proportionate to the willingness to take vaccines, thereby increasing the vaccination rate. In this context, the first and foremost priority of the educational institutes should be the evaluation of the knowledge and attitude of their students towards the flu vaccine.
Encouraging the university-wide uptake of flu vaccine, various public-level interventions are also required. Incentives (coupons, give aways, etc.) might play an additional motivating role and encourage the students to get the flu jab. As discussed earlier, the provision of free vaccines at the institutional or national level will significantly contribute to achieving the targeted vaccine coverage. It is pertinent to mention that the motivation of the students to take the vaccine is potentially transmittable to their family, friends, and relatives. Moreover, the students from healthcare disciplines could play an additional role in the vaccination campaign by sensing it as their professional and ethical duty by considering the fact that they will be healthcare professionals in the future. An efficient way of increasing the vaccine coverage is to introduce interventions that would specifically target the vaccine-hesitant and ambivalent population. Understanding the perception of students and addressing the knowledge gaps by introducing educational programs will boost the awareness of the students, especially those from non-health science disciplines.
The present study is limited by self-reporting of vaccine uptake status which could be a potential bias. Additionally, convenient sampling was used which limits the generalizability of the outcomes. There is a probability that the students who participated in the survey could be different from those who did not participate. This could lead to over-estimate and under-estimate of the vaccination rate, barriers, and willingness score. Furthermore, due to the cross-sectional study design, we were unable to establish causal inferences even though the association between the variables might exist. This study was single-centered and might not be extrapolated to the students of other universities. Moreover, the sampled population may have the bias of having the population who was less inclined to get vaccinated. Nevertheless, this study is strengthened by the large sample size and the first representation of the flu vaccine status among students from health and non-health science disciplines in a public university in Saudi Arabia. The implications of this study can be considered for all universities, as public and private educational institutes follow similar policies and procedures to the Ministry of Education. Moreover, a heterogeneous study population is another strength of this survey.

CONCLUSIONS
This study underscored the unsatisfactory flu vaccination rate among university students. The study participants demonstrated poor knowledge and were less inclined to receive the flu vaccine in the future. Lack of recommendation from the physicians, negative perceptions towards the flu vaccine, and difficult accessibility were found as significant barriers to the vaccine uptake. The knowledge, barriers, and willingness widely varied across students from various disciplines. Lower than recommended vaccination coverage is a global concern for vaccine-preventable influenza. The vaccination rate in this study is expected to be improved as per the willingness of students. A multidimensional approach needs to be adopted to enhance the vaccination coverage such as educational campaigns, awareness seminars, and safe and free provision of vaccines at the university level. Continued education and communication play a vital role in changing the perception over time, hence, encouraging students to achieve high vaccine coverage. Moreover, future research could focus on multi-institutional qualitative studies including on the safety and efficacy of the influenza vaccine.

ADDITIONAL INFORMATION AND DECLARATIONS Funding
This work was funded by the Deanship of Scientific Research at Jouf University under Grant No. (DSR-2021-01-0334). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.