Abstract：A girl, aged 22 months, attended the hospital due to recurrent vulvar rashes for more than half a year. Skin biopsy showed Langerhans cell histiocytosis, and evaluation of systemic conditions showed no systemic involvement. Therefore, the girl was diagnosed with Langerhans cell histiocytosis (skin type). In conclusion, for rashes on the vulva alone, if there are no specific clinical manifestations, the possibility of Langerhans cell histiocytosis should be considered after molluscum contagiosum, sexually transmitted diseases, and Fordyce disease are excluded.
I Ke-Yao,TANG Jian-Ping,JIANG Yan-Ling et al. Recurrent vulvar rashes in a girl aged 22 months for more than half a year[J]. CJCP, 2021, 23(1): 98-102.
Zamora AB, Simón MP, Sánchez AT, et al. Adult colloid milium. An underdiagnosed and difficult to treat entity[J]. Rev Med Hosp Gen Méx, 2016, 79(1):21-25.
Pan Z, Sharma S, Sharma P. Primary Langerhans cell histiocytosis of the vulva:report of a case and brief review of the literature[J]. Indian J Pathol Microbiol, 2009, 52(1):65-68.
[10]
Emile JF, Abla O, Fraitag S, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages[J]. Blood, 2016, 127(22):2672-2681.
[11]
Zinn DJ, Chakraborty R, Allen CE. Langerhans cell histiocytosis:emerging insights and clinical implications[J]. Oncology (Williston Park), 2016, 30(2):122-132.
[12]
DiCaprio MR, Roberts TT. Diagnosis and management of Langerhans cell histiocytosis[J]. J Am Acad Orthop Surg, 2014, 22(10):643-652.
[13]
Chang JC, Blake DG, Leung BV, et al. Langerhans cell histiocytosis associated with lichen sclerosus of the vulva:case report and review of the literature[J]. J Cutan Pathol, 2013, 40(2):279-283.
[14]
Badalian-Very G, Vergilio JA, Degar BA, et al. Recurrent BRAF mutations in Langerhans cell histiocytosis[J]. Blood, 2010, 116(11):1919-1923.
[15]
Kurt S, Canda MT, Kopuz A, et al. Diagnosis of primary Langerhans cell histiocytosis of the vulva in a postmenopausal woman[J]. Case Rep Obstet Gynecol, 2013, 2013:962670.
Subramaniyan R, Ramachandran R, Rajangam G, et al. Purely cutaneous Langerhans cell histiocytosis presenting as an ulcer on the chin in an elderly man successfully treated with thalidomide[J]. Indian Dermatol Online J, 2015, 6(6):407-409.
[20]
Ishigaki H, Hatta N, Yamada M, et al. Localised vulva Langerhans cell histiocytosis[J]. Eur J Dermatol, 2004, 14(6):412-414.
[21]
Venizelos ID, Mandala E, Tatsiou ZA, et al. Primary Langerhans cell histiocytosis of the vulva[J]. Int J Gynecol Pathol, 2006, 25(1):48-51.
