Research Article | Volume: 6, Issue: 4, April, 2016

Free radical scavenger activity of chitosan and its aminated derivative

Tamer M Tamer,  Katarina Valachová,  Mohamed Samir Mohyeldin,  Ladislav Soltes   
Tamer M Tamer1, Katarina Valachová2, Mohamed Samir Mohyeldin2, Ladislav Soltes3

1Polymer research department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technological Applications. New Borg El- Arab, Alexandria, Egypt.

2Laboratory of Bioorganic Chemistry of Drugs, Institute of Experimental Pharmacology and Toxicology, SK-81404 Bratislava, Slovakia.

3Chemistry Department, Faculty of Science, University of Jeddah, Osfan, P. O. Box: 80203, Jeddah 21589, Saudi Arabia.

Open Access   

Published:  Apr 30, 2016

DOI: 10.7324/JAPS.2016.60428
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Abstract

Antioxidants may have a positive effect on human health since they can protect the human body against deterioration by reactive oxygen species (ROS). Chitosan has many promising properties as nontoxic, biocompatible, biodegradable, antimicrobial and recently antioxidant properties. Most of the reports on the antioxidant activity of chitosan are based on the ability of amine and hydroxyl group to scavenge free radical to form stable macromolecular radical. In the current study, a new chitosan derivative with extra free amine groups was evaluated using two popular antioxidant evaluation methods (uninhibited/inhibited hyaluronan degradation and decolorization of ABTS method). The result obtained in our study show increase the activity of aminated chitosan for scavenging free radicals than chitosan itself.


Keyword:     Chitosan Aminated chitosan Antioxidant Rotational viscometer ABTS Hyaluronan.

Citation:

Tamer TM, Valachová K, Mohyeldin MS, Soltes L. Free radical scavenger activity of chitosan and its aminated derivative. J App Pharm Sci, 2016; 6 (04): 195-201.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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