Research Article | Volume: 8, Issue: 2, February, 2018

Anti-inflammatory and antioxidant activity of salicylic acid conjugated dihydropyrazoline analogues

Naveen Puttaswamy ,  Rekha N D,  Lakshmi Ranganatha V,  Prashanth T ,  Shaukath Ara Khanum   
Naveen Puttaswamy1 & 2, Rekha N D3, Lakshmi Ranganatha V4, Prashanth T1 & 2, Shaukath Ara Khanum2

1Department of Chemistry, JSS College of Arts, Commerce & Science, Ooty Road, Mysuru - 570025.

2Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysuru - 570005.

3Department of Biotechnology, JSS College of Arts, Commerce & Science, Ooty Road, Mysuru - 570025.

4Department of Chemistry, The National Institute of Engineering, Mysuru - 570015.

Open Access   

Published:  Feb 27, 2018

DOI: 10.7324/JAPS.2018.8209
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Abstract

Syntheses of substituted salicylic acid appended pyrazoline analogues (7a-j) via 1,3-dipolar cycloaddition were reported earlier. In the present investigation we have performed the anti-inflammatory activity by phospholipase A2 (PLA2) inhibition and in vitro antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl, nitric oxide, hydroxyl radical scavenging assay and ferrous ion chelating assay wherein compounds 7d, 7h, 7i and 7j have shown maximum anti-inflammatory activity. Further, compounds 7d, 7f and 7h were proved to be excellent free radical scavengers.


Keyword:     13-dipolar cycloadditionanti-inflammatory anti-oxidantphospholipase A2.

Citation:

Puttaswamy N, Rekha ND, Lakshmi Ranganatha V, Prashanth T, Khanum SA. Anti-inflammatory and antioxidant activity of salicylic acid conjugated dihydropyrazoline analogues. J App Pharm Sci, 2018; 8(02): 060-064.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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