Persistent Identifier
|
doi:10.7281/T1/XGVRX0 |
Publication Date
|
2022-06-23 |
Title
| Data associated with the publication: Nanoscale boreceptor layers comprising carboxylated polythiophene for organic electrochemical transistor-based biosensors |
Author
| Song, Yunjia (Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD. USA)
Lamberty, Zachary D. (Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD. USA) - ORCID: 0000-0003-2948-9818
Liang, Junhao (Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD. USA)
Pellitero, Miguel A. (Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, USA) - ORCID: 0000-0001-8739-2542
Wagner, Justine S. (Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD. USA) - ORCID: 0000-0003-4647-0449
Jumai’an, Eugenie (Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD. USA)
Bevan, Michael A. (Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD. USA) - ORCID: 0000-0002-9368-4899
Frechette, Joelle (Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD. USA) - ORCID: 0000-0001-5680-6554
Currás, Netzahualcóyotl Arroyo (Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD. USA) - ORCID: 0000-0001-8739-2542
Katz, Howard E. (Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD. USA) - ORCID: 0000-0001-8739-2542 |
Point of Contact
|
Use email button above to contact.
For questions about the data contact Howard E. Katz via hekatz@jhu.edu. (Department of Materials Science and Engineering, Johns Hopkins University)
For questions about access to the data contact Johns Hopkins University Data Services via dataservices@jhu.edu. (Johns Hopkins University Data Services) |
Description
| From the publication abstract: We investigated the carboxylated conjugated polymer poly 3-(3-carboxypropyl)thiophene-2,5-diyl as a nanosized (200–350 nm) biomolecule receptor layer on the channel of organic electrochemical transistor (OECT) devices. Myelin basic protein, SARS-CoV-2 spike glycoprotein S1, and their antibodies (10 nm size scale) were alternately used in the attached molecule form as receptors and analytes. Sub-ng detection in buffer was observed, and response to S1 was also obtained in clinical serum. Changes in threshold voltage and current output from OECT transfer curves and measurements of open circuit potential between receptor layers and a reference electrode provided complementary responses and insight into the response mechanisms, guiding further development of electrochemical field-effect and voltammetric protein sensors based on polymeric active layers with nanoscale functionality. |
Subject
| Chemistry; Engineering; Medicine, Health and Life Sciences |
Keyword
| conjugated polymers
biosensors
myelin basic protein
SARS-CoV-2
OECT
open circuit potential
zeta potential |
Related Publication
| Song, Y.; Lamberty, Z. D.; Liang, J.; Aller Pellitero, M.; Wagner, J. S.; Jumai’an, E.; Bevan, M. A.; Frechette, J.; Arroyo-Currás, N.; Katz, H. E. Nanoscale Bioreceptor Layers Comprising Carboxylated Polythiophene for Organic Electrochemical Transistor-Based Biosensors. ACS Appl. Nano Mater. 2021, 4 (12), 13459–13468. doi: 10.1021/acsanm.1c02949 https://doi.org/10.1021/acsanm.1c02949 |
Language
| English |
Producer
| Katz, Howard E. (Department of Materials Science and Engineering, Johns Hopkins University) https://engineering.jhu.edu/HowardKatzResearchGroup/ |
Production Date
| 2022-03 |
Production Location
| Johns Hopkins University |
Funding Information
| National Science Foundation: DMR: 1807292 |
Distributor
| Johns Hopkins University Data Services (JHUDS) https://dataservices.library.jhu.edu/ |
Depositor
| Katz, Howard E. |
Deposit Date
| 2022-04 |