A case of pityriasis rosea of vidal accompanied by neurofibromatosis type 1

A 23-year-old woman came to our outpatient clinic with a two-weeks history of pruritic reddish lesions on her armpits and groins. Her past medical history was consistent with neurofibromatosis type 1 (NF-1), for which she was under routine follow-up. Upon dermatological examination we observed multiple erythematous to violaceous coalescent and infiltrative plaques with central clearing which were annular and polycyclic in shape on bilateral proximal femoral regions (Figs 1-3) and erythematous papules tending to merge into smaller plaques on left axillary area (Fig. 4). Dermatological examination also disclosed several café-au-lait macules, one of which was greatest in diameter on left lateral brachial region and axillary freckling which was more marked on the left side (Fig. 4). A lesional skin biopsy from erythematous plaques revealed extravasation of red blood cells in dermis, dermal perivascular lymphocytic infiltration and focal spongiosis in the epidermis (Figs 5-7). Based on history, clinical and histopathological findings a diagnosis of pityriasis rosea circinata et marginata of Vidal (PRV) accompanied by NF-1 was made. The patient was prescribed topical corticosteroids and at the one month follow up visit, the lesions were significantly improved.


COMMENTS
We read with pleasure the case report by Yorulmaz A et al on the occurrence of pityriasis circiné et marginé which is a variant of pityriasis rosea (PR) in a 23-year-old lady with known neurofibromatosis type 1 (NF-1) [1].
We agree to both diagnoses [2][3][4].Both diseases are uncommon, but definitely not rare.We have no data on the prevalence of NF-1 in Turkey.In the United Kingdom, the prevalence is around 1:4560 [5], with the prevalence at birth being 1:2699 [5].The prevalences of NF-1 for six-year-old German children, and 9-11 year-old children in Cuba, are 1:2996 [6] and 1:1141 [7] respectively.The prevalence of PR is around 1:167 [8].This means that if a clinic follows 200 patients with NF-1, and sees them once every year, around 1.20 patient with PR would be expected to be seen.
While reporting them concomitantly in one individual, we might consider exploring the mechanisms as to whether these two diseases: (1) are merely coincidental; (2) are being innocent bystanders (NF-1); (3) are related to the same confounder(s), and (4) have underlying immunopathogenetic connections, which could be risk factors, precipitating factors, or be genuine causal relationships.
For patient with NF-1, the immunological system is compromised to various extents [9][10][11][12].The processes are not comprehensively known, although it is likely that multiple immunological pathways and cellular mechanisms reduce the antigen-processing and antigen-presenting cells in NF-1 [12].Moreover, large groups of immune function genes in human Schwann cells are down-regulated in NF-1 [13].Acute phase reactants such as interleukins are reported to be adversely affected in NF-1 [13].Other than systematic effects, topical immunological responses could also be compromised [11], which might facilitate the inoculation of viruses at the herald patch, a postulation not yet substantiated.
A simplified immunopathological sequence would be: primary viral infection in childhood, the body then launches a primary and non-specific immunological response, then clonal expansion of T-cells (memory cells), then life-long latent infection of the virus in the peripheral blood mononuclear cells, then physical or psychological stresses together with NF-1 weakening the immunity, then endogenous reactivation of the viruses, then secondary immunological response (mainly by cell-mediated immunity), then the visible PR rash.The immunological basis for the predilected sites of lesions in bilateral axillae and groins in pityriasis circiné et marginé, however, is completely unknown.Fo r o t h e r p a r a v i r a l ex a n t h e m s , e r u p t i v e pseudoangiomatosis was reported to be associated with hospitalisations and treatment for cancers [14].It was postulated that relative immunocompromisation is the missing link.We have reported the association of Gianotti-Crosti syndrome -another paraviral exanthem -and hyperimmunoglobulinaemia E syndrome (Job's syndrome), which is a congenital immunodeficiency disease [15].Whether relative immunocompromisation is associated with other paraviral exanthems, such as asymmetric periflexural exanthem (unilateral laterothoracic exanthem) and papular-purpuric gloves and socks syndrome, is yet to be investigated.
Finally, we congratulate Yorulmaz A and his colleagues for such an outstanding piece of work which can be applied to patients immediately.We humbly recommend Yorulmaz A et al and other investigators to explore the possible associations between relative immunocompromisation and PR or other paraviral exanthems.
The association of pityriasis circiné et marginé and neurofibromatosis type 1