1996 Volume 49 Issue 5 Pages 438-446
A detailed analysis of the secondary metabolite pattern produced by Streptomyces griseoviridis (strain FH-S 1832) using a chemical screening method resulted in the detection, isolation and structure elucidation of new 14-membered lactones of the cineromycin B-type [dehydrocineromycin B (5), oxycineromycin B (7), and 2, 3-dihydrocineromycin B (8)], as well as new γ-lactones related to nigrosporalactone and 4, 5-dihydroxy-octa-2, 6-dienoic acid esters named musacins A to F (10, 13-15, 17, 18 and 21). The constitution of these metabolites were deduced from spectroscopic data as well as chemical transformations. The configuration of musacin D (10) was determined by derivatization with chiral acids (Helmchen's method).
