PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE II. STRUCTURAL ELUCIDATION OF PEPTJCINNAMIN E

KAZURO SHIOMI; HONG YANG; JUNJI INOKOSHI; DIDIER VAN DER PYL; AKIRA NAKAGAWA; HIDEO TAKESHIMA; SATOSHI OMURA

doi:10.7164/antibiotics.46.229

PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE

II. STRUCTURAL ELUCIDATION OF PEPTJCINNAMIN E

KAZURO SHIOMI, HONG YANG, JUNJI INOKOSHI, DIDIER VAN DER PYL, AKIRA NAKAGAWA, HIDEO TAKESHIMA, SATOSHI OMURA

Author information

JOURNAL FREE ACCESS

1993 Volume 46 Issue 2 Pages 229-234

DOI https://doi.org/10.7164/antibiotics.46.229

Details

Abstract

Structure of novel farnesyl transferase inhibitor, pepticinnamin E, is elucidated by NMR study. Pepticinnamin E is composed of five amino acids and o-pentenylcinnamic acid, having a molecular weight of 907. C-terminal glycylserine of the compounds is in the cyclized diketopiperazine form.

Corresponding author

Register with J-STAGE for free!