The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
BMY-28190, A NOVEL ANTIVIRAL ANTIBIOTIC COMPLEX
HIROAKI OHKUMAOSAMU TENMYOMASATAKA KONISHITOSHIKAZU OKIHIROSHI KAWAGUCHI
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1988 Volume 41 Issue 7 Pages 849-854

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Abstract

BMY-28190, an antibiotic complex active against herpes simplex virus type 1 (HSV-1) was produced by the cultured broth of Stmptoalloteichus hindustanus sp. nov., a producing strain of tallysomycins A and B1). The antibiotic complex was recovered from the broth with Amberlite IRC-50 resin and separated from the coproduced tallysomycins and nebramycins by a series of chromatographies. BMY-28190 exhibited weak inhibitory activity toward Gram-positive and Gram-negative bacteria and strong inhibitory activity toward HSV-1. Structural studies disclosed that BMY-28190 is a move! complex of Υ-poly-D-α, Υ-diammobutyric acids with an average MW of 5, 130.

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© Japan Antibiotics Research Association
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