NEW TYLOSIN ANALOGS PRODUCED BY MUTANTS OF STREPTOMYCES FRADIAE

KOHKI KIYOSHIMA; KAZUAKI TAKADA; MASAO YAMAMOTO; KATSURO KUBO; ROKURO OKAMOTO; YASUO FUKAGAWA; TOMOYUKI ISHIKURA; HIROSHI NAGANAWA; TSUTOMU SAWA; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.40.1123

NEW TYLOSIN ANALOGS PRODUCED BY MUTANTS OF STREPTOMYCES FRADIAE

KOHKI KIYOSHIMA, KAZUAKI TAKADA, MASAO YAMAMOTO, KATSURO KUBO, ROKURO OKAMOTO, YASUO FUKAGAWA, TOMOYUKI ISHIKURA, HIROSHI NAGANAWA, TSUTOMU SAWA, TOMIO TAKEUCHI, HAMAO UMEZAWA

Author information

KOHKI KIYOSHIMA
Sanraku Inc., Central Research Laboratories
KAZUAKI TAKADA
Sanraku Inc., Central Research Laboratories
MASAO YAMAMOTO
Sanraku Inc., Central Research Laboratories
KATSURO KUBO
Sanraku Inc., Central Research Laboratories
ROKURO OKAMOTO
Sanraku Inc., Central Research Laboratories
YASUO FUKAGAWA
Sanraku Inc., Central Research Laboratories
TOMOYUKI ISHIKURA
Sanraku Inc., Central Research Laboratories
HIROSHI NAGANAWA
Institute of Microbial Chemistry
TSUTOMU SAWA
Institute of Microbial Chemistry
TOMIO TAKEUCHI
Institute of Microbial Chemistry
HAMAO UMEZAWA
Institute of Microbial Chemistry

JOURNAL FREE ACCESS

1987 Volume 40 Issue 8 Pages 1123-1130

DOI https://doi.org/10.7164/antibiotics.40.1123

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Abstract

2'''-Demethoxytylosin (component IIIc), 2'''-demethoxy-4'''-epi-tylosin (component IIId) and 2'''-O-demethyltylosin (component Vb) were produced by blocked mutant strains of Streptomyces fradiae. Fermentation, isolation, structure determination and biosynthetic considerations of these tylosin analogs are described.

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