CHEMICAL MODIFICATION OF HERBIMYCIN A SYNTHESIS AND <i>IN VIVO</i> ANTITUMOR ACTIVITIES OF HALOGENATED AND OTHER RELATED DERIVATIVES OF HERBIMYCIN A

KIYOSHI SHIBATA; SADAYOSHI SATSUMABAYASHI; HIROSHI SANO; KANKI KOMIYAMA; AKIRA NAKAGAWA; SATOSHI OMURA

doi:10.7164/antibiotics.39.415

CHEMICAL MODIFICATION OF HERBIMYCIN A

SYNTHESIS AND IN VIVO ANTITUMOR ACTIVITIES OF HALOGENATED AND OTHER RELATED DERIVATIVES OF HERBIMYCIN A

KIYOSHI SHIBATA, SADAYOSHI SATSUMABAYASHI, HIROSHI SANO, KANKI KOMIYAMA, AKIRA NAKAGAWA, SATOSHI OMURA

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JOURNAL FREE ACCESS

1986 Volume 39 Issue 3 Pages 415-423

DOI https://doi.org/10.7164/antibiotics.39.415

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Abstract

Several halogenated and other related derivatives of herbimycin A have been synthesized and evaluated in vivo for their activities against Ehrlich ascites carcinoma. Some of these derivatives show higher activities than herbimycin A. Among them the derivatives modified at the 4, 5, 6, and 7-positions of the ansa chain showed particularly high activities.

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