AN INHIBITOR OF (Na+, K+)-ATPase PRODUCED BY STREPTOMYCES PSEUDOVENEZUELAE MF722-02; PURIFICATION AND PROPERTIES

MAKOTO HORI; HIDETOSHI EGUCHI; MASAMI TSUCHIYA; TAKESHI HARA; HIROSHI NAGANAWA; TSUYOSHI TAMAMURA; HAMAO UMEZAWA

doi:10.7164/antibiotics.35.1448

AN INHIBITOR OF (Na⁺, K⁺)-ATPase PRODUCED BY STREPTOMYCES PSEUDOVENEZUELAE MF722-02; PURIFICATION AND PROPERTIES

MAKOTO HORI, HIDETOSHI EGUCHI, MASAMI TSUCHIYA, TAKESHI HARA, HIROSHI NAGANAWA, TSUYOSHI TAMAMURA, HAMAO UMEZAWA

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JOURNAL FREE ACCESS

1982 Volume 35 Issue 11 Pages 1448-1453

DOI https://doi.org/10.7164/antibiotics.35.1448

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Abstract

A culture product of Streptomyces pseudovenezuelae MF722-02, with a molecular formula of C₂₉H₃₂N₂O₇, was isolated as yellow needles from culture broths and mycelia of the organism by means of a series of solvent extraction, column chromatography and crystallization. The antibiotic is active against some Gram-positive bacteria, inhibits growth in vitro of cells of mouse leukemia L-1210, prolongs the life span of mice inoculated with the leukemia cells, enhances deoxycholate-induced hemolysis in vitro and inhibits (Na⁺, K⁺)-ATPase in vitro.

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