The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
A NEW ANTHELMINTIC CYCLODEPSIPEPTIDE, PF1022A
TORU SASAKI, MASAYUKI TAKAGI, TAKASI YAGUCHI, SHINJI MIYADOH, TADAAKI OKADA, MASAO KOYAMA
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1992 Volume 45 Issue 5 Pages 692-697

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Abstract

The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (PERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl-D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic analyses and chemical studies.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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