SITE OF REGULATION OF NANAOMYCIN BIOSYNTHESIS BY INORGANIC PHOSPHATE
1990 Volume 43 Issue 1 Pages 83-87
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1990 Volume 43 Issue 1 Pages 83-87
The site of regulation of nanaomycin biosynthesis by inorganic phosphate was studied with washed cells previously grown in a chemically defined medium containing a high- or low-phosphate concentration. The former mycelia produced only about one-tenth the amount of nanaomycin A from acetate as did the latter mycelia. On the other hand, the bioconversions of nanaomycin D to A and nanaomycin A to E were only slightly affected. It is suggested that the site of regulation of nanaomycin biosynthesis by inorganic phosphate lies within steps between acetate and nanaomycin D.
