KAZUSAMYCIN B, A NOVEL ANTITUMOR ANTIBIOTIC

KOHTAROU FUNAISHI; KENJI KAWAMURA; YASUYUKI SUGIURA; NORIYUKI NAKAHORI; EISAKU YOSHIDA; MASANORI OKANISHI; IWAO UMEZAWA; SHINJI FUNAYAMA; KANKI KOMIYAMA

doi:10.7164/antibiotics.40.778

KOHTAROU FUNAISHI, KENJI KAWAMURA, YASUYUKI SUGIURA, NORIYUKI NAKAHORI, EISAKU YOSHIDA, MASANORI OKANISHI, IWAO UMEZAWA, SHINJI FUNAYAMA, KANKI KOMIYAMA

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KOHTAROU FUNAISHI
Exploratory Research Laboratories, Banyu Pharmaceutical Co., Ltd.
KENJI KAWAMURA
Exploratory Research Laboratories, Banyu Pharmaceutical Co., Ltd.
YASUYUKI SUGIURA
Exploratory Research Laboratories, Banyu Pharmaceutical Co., Ltd.
NORIYUKI NAKAHORI
Exploratory Research Laboratories, Banyu Pharmaceutical Co., Ltd.
EISAKU YOSHIDA
Exploratory Research Laboratories, Banyu Pharmaceutical Co., Ltd.
MASANORI OKANISHI
Exploratory Research Laboratories, Banyu Pharmaceutical Co., Ltd.
IWAO UMEZAWA
The Kitasato Institute
SHINJI FUNAYAMA
The Kitasato Institute
KANKI KOMIYAMA
The Kitasato Institute

JOURNAL FREE ACCESS

1987 Volume 40 Issue 6 Pages 778-785

DOI https://doi.org/10.7164/antibiotics.40.778

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Abstract

A novel antibiotic, kazusamycin B (C₃₂H₄₆O₇, MW 542), was isolated from the fermentation broth of Streptomyces sp. No. 81-484 and the structure was established mainly on the basis of its physico-chemical properties. Unambiguous ¹³C NMR spectral analysis of kazusamycin B has been also accomplished. Kazusamycin B possesses potent cytocidal activities against L1210 (IC₅₀ 0.0018 μg/ml) and P388 (IC100 0.0016 μg/ml) leukemia cells in vitro.

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