The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
A STREPTOTHRICIN-LIKE ANTIBIOTIC MIXTURE, A-269 A (AND A-269A')
YUTAKA KIDO, TAROU FURUIE, KEITAROU SUZUKI, KYOKO SAKAMOTO, YOSHITO YOKOYAMA, MASARU UYEDA, JUN-EI KINJYO, SHYOJI YAHARA, TOSHIHIRO NOHARA, MOTOO SHIBATA
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1987 Volume 40 Issue 12 Pages 1698-1706

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Abstract

A streptothricin-like antibiotic, A-269A (referred to as A-269A hereafter) was isolated from the culture broth of Streptomyces sp., strain No. A-269. In this paper, the characterization of the producer, and the production, isolation, physico-chemical properties and biological properties of A-269 A are reported. The structure of the antibiotic was also examined by 1H NMR, 13C NMR and fast atom bombardment mass spectra studies. From the spectroscopic data, A-269A was assumed to be a mixture of antibiotic LL-BL 136 and an isomeric compound in which the carbamoyl group is substituted on C-12' hydroxyl instead of C-10 hydroxyl.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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