SEMISYNTHESIS OF A23187 (CALCIMYCIN) ANALOGS
II. INTRODUCTION OF A METHYL GROUP ON THE BENZOXAZOLE RING
1984 Volume 37 Issue 6 Pages 627-634
Details
1984 Volume 37 Issue 6 Pages 627-634
Semisynthesis of two demethylamino A23187 with a methyl group in the 4- or 5-position on the benzene ring were carried out via the cleavage of A23187 oxazole ring and rebuilding of modified benzoxazoles. These compounds were shown to release Ca++ and Mg++ from mitochondria and to keep in part the antibacterial activity of the natural metabolite.
