STUDIES ON NEW VASODILATORS, WS-1228 A AND B I. DISCOVERY, TAXONOMY, ISOLATION AND CHARACTERIZATION

KEIZO YOSHIDA; MASANORI OKAMOTO; KAZUYOSHI UMEHARA; MORITA IWAMI; MASANOBU KOHSAKA; HATSUO AOKI; HIROSHI IMANAKA

doi:10.7164/antibiotics.35.151

STUDIES ON NEW VASODILATORS, WS-1228 A AND B

I. DISCOVERY, TAXONOMY, ISOLATION AND CHARACTERIZATION

KEIZO YOSHIDA, MASANORI OKAMOTO, KAZUYOSHI UMEHARA, MORITA IWAMI, MASANOBU KOHSAKA, HATSUO AOKI, HIROSHI IMANAKA

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JOURNAL FREE ACCESS

1982 Volume 35 Issue 2 Pages 151-156

DOI https://doi.org/10.7164/antibiotics.35.151

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Abstract

New vasodilators, designated WS-1228 A and B have been discovered in the culture filtrate of a strain of Streptomyces aureofaciens. The active compounds were purified by column chromatography with Diaion HP-20 and silica gel, and finally separated from each other by high performance liquid chromatography. They were obtained as pale yellow crystals and their molecular formulae were both C₁₁H₁₇N₃O.

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