NEW ANTHRACYCLINE METABOLITES FROM MUTANT STRAINS OF STREPTOMYCES GALILAEUS MA144-M1 II. STRUCTURE OF 2-HYDROXYAKLAVINONE AND NEW AKLAVINONE GLYCOSIDES

YASUE MATSUZAWA; AKIHIRO YOSHIMOTO; NORIO SHIBAMOTO; HIROYASU TOBE; TOSHIKAZU OKI; HIROSHI NAGANAWA; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.34.959

NEW ANTHRACYCLINE METABOLITES FROM MUTANT STRAINS OF STREPTOMYCES GALILAEUS MA144-M1

II. STRUCTURE OF 2-HYDROXYAKLAVINONE AND NEW AKLAVINONE GLYCOSIDES

YASUE MATSUZAWA, AKIHIRO YOSHIMOTO, NORIO SHIBAMOTO, HIROYASU TOBE, TOSHIKAZU OKI, HIROSHI NAGANAWA, TOMIO TAKEUCHI, HAMAO UMEZAWA

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JOURNAL FREE ACCESS

1981 Volume 34 Issue 8 Pages 959-964

DOI https://doi.org/10.7164/antibiotics.34.959

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Abstract

Four blocked mutants of aclacinomycin-producing Streptomyces galilaeus MA144-M1 produced new anthracyclinones; 2-hydroxyaklavinone, its non-esterified analog and 2-hydroxy-7-deoxyaklavi none, several new anthracyclines; 2-deoxyfucosyl-2-deoxyfucosyl-rhodosaminylaklavinone (MA144 U1), 2-deoxyfucosyl-rhodosaminylaklavinone (MA144 U2) and five aklavinone glycosides devoid of amino sugar, designated as MA144 U5, U6, U7, U8 and U9.

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