CJ-15, 183, a New Inhibitor of Squalene Synthase Produced by a Fungus, Aspergillus aculeatm

SHUZO WATANABE; HIDEO HIRAI; MASARU ISHIGURO; TAKAHITO KAMBARA; YASUHIRO KOJIMA; TOMOYUKI MATSUNAGA; HIROYUKI NISHIDA; YUMIKO SUZUKI; AYUMU SUGIURA; H. JAMES HARWOOD; LIANG HSIUNG HUANG; NAKAO KOJIMA

doi:10.7164/antibiotics.54.904

CJ-15, 183, a New Inhibitor of Squalene Synthase Produced by a Fungus, Aspergillus aculeatm

SHUZO WATANABE, HIDEO HIRAI, MASARU ISHIGURO, TAKAHITO KAMBARA, YASUHIRO KOJIMA, TOMOYUKI MATSUNAGA, HIROYUKI NISHIDA, YUMIKO SUZUKI, AYUMU SUGIURA, H. JAMES HARWOOD, LIANG HSIUNG HUANG, NAKAO KOJIMA

Author information

SHUZO WATANABE
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
HIDEO HIRAI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
MASARU ISHIGURO
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
TAKAHITO KAMBARA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
YASUHIRO KOJIMA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
TOMOYUKI MATSUNAGA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
HIROYUKI NISHIDA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
YUMIKO SUZUKI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
AYUMU SUGIURA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc.
H. JAMES HARWOOD
PGRD, Groton Laboratories, Pfizer Inc.
LIANG HSIUNG HUANG
PGRD, Groton Laboratories, Pfizer Inc.
NAKAO KOJIMA
Faculty of Pharmacy, Meijo University

JOURNAL FREE ACCESS

2001 Volume 54 Issue 11 Pages 904-910

DOI https://doi.org/10.7164/antibiotics.54.904

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Abstract

A new squalene synthase (SSase) inhibitor, CJ-15, 183 (I) was isolated from the fermentation broth of a fungus, Aspergillus aculeatus CL38916. The compound potently inhibited rat liver and Candida albicans microsomal SSases and also inhibited the human enzyme. It also showed antifungal activities against filamentous fungi and a yeast. The structurewas determined to be an aliphatic tetracarboxylic acid compound consisting of an alkyl γ-lactone, malic acid and isocitric acid moieties by spectroscopic studies.

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