The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Production of a Family of Kinase-inhibiting Lactones from Fungal Fermentations
ANNE DOMBROWSKI, ROSALIND JENKINS, SUSAN RAGHOOBAR, GERALD BILLS, JON POLISHOOK, FERNANDO PELÁEZ, BRUCE BURGESS, ANNIE ZHAO, LEEYUAN HUANG, YAN ZHANG, MICHAEL GOETZ
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1999 Volume 52 Issue 12 Pages 1077-1085

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Abstract

During the course of our screening for natural products from fungi, extracts of several cultures were found to make a family of related resorcylic acid lactone compounds, which are potent inhibitors of MEK kinase. Comparative and empirical studies of fermentation conditions improved the titers of the compounds of interest. Striking changes in the ratios and amounts of the major and minor compounds in some cases were achieved by manipulations of media composition.

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The Journal of Antibiotics, Series A

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