Structure and Biosynthesis of FD-594; a New Antitumor Antibiotic
1998 Volume 51 Issue 3 Pages 288-295
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1998 Volume 51 Issue 3 Pages 288-295
The structure of a novel antitumor antibiotics FD-594 (1), produced by Streptomyces sp. TA-0256, was determined to have a glycosylated pyrano[4′, 3′:6, 7]naphtho[1, 2-b]-xanthene skeleton by means of spectral data. The biosynthetic studies of the chromophore of 1 was also carried out by feeding experiments with [1-13C]-, [2-13C]-, and [1, 2-13C2]sodium acetate. The labeling pattern was determined by 13C NMR including 2D INADEQUATE experiments, which allowed us to elucidate that the chromophore of 1 is derived from 14 acetate, followed by the loss of one carbon atom.
