A-72363 A-l, A-2, and C, Novel Heparanase Inhibitors from Streptomyces nobilis SANK 60192 II. Biological Activities

YUMI KAWASE; MASAAKI TAKAHASHI; TOSHIO TAKATSU; MASATOSHI ARAI; MOTOWO NAKAJIMA; KAZUHIKO TANZAWA

doi:10.7164/antibiotics.49.61

A-72363 A-l, A-2, and C, Novel Heparanase Inhibitors from Streptomyces nobilis SANK 60192

II. Biological Activities

YUMI KAWASE, MASAAKI TAKAHASHI, TOSHIO TAKATSU, MASATOSHI ARAI, MOTOWO NAKAJIMA, KAZUHIKO TANZAWA

Author information

JOURNAL FREE ACCESS

1996 Volume 49 Issue 1 Pages 61-64

DOI https://doi.org/10.7164/antibiotics.49.61

Details

Abstract

Inhibitory activities of A-72363 A-1, A-2, and C, the diastereomers of a neuraminidase inhibitor siastain B, against various glycosidases were tested in comparison to siastatin B. Despite these compounds differing only in their configuration, each compound showed strikingly different specificities towards the various glycosidases tested. A-72363 C inhibited bovine liver β-glucuronidase and tumor cell heparanase with IC₅₀ values of 1.6 μM and 12 μM, respectively.

Corresponding author

Register with J-STAGE for free!