The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
ISOLATION AND STRUCTURE ELUCIDATION OF TWO NEW CALPAIN INHIBITORS FROM Streptomyces griseus
M. ESTELA ALVAREZ, DAVID R. HOUCK, CAROLE B. WHITE, JAMES E. BROWNELL, MARK A. BOBKO, CHARLES A. RODGER, MARY B. STAWICKI, HAO H. SUN, AMANDA M. GILLUM, RAYMOND COOPER
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1994 Volume 47 Issue 11 Pages 1195-1201

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Abstract

Two new peptides, a diketopiperazine of N-methyltyrosine (1) and a tetrapeptide containing N-methyltyrosine (2), were isolated from an actinomycete strain Streptomyces griseujs. These compounds inhibit the enzyme calpain in the micromolar range and were characterized on the basis of spectroscopic analysis, amino acid analysis and sequencing. The structure of the tetrapeptide N-methyltyrosyl-N-methyltyrosyl-leucyl-alanine (2), was also confirmed by total synthesis.

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The Journal of Antibiotics, Series A

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