QUINOLIDOMICINS A1, A2 AND B1, NOVEL 60-MEMBERED MACROLIDE ANTIBIOTICS I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

YOICHI HAYAKAWA; MICHIKO MATSUOKA; KAZUO SHIN-YA; HARUO SETO

doi:10.7164/antibiotics.46.1557

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

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Volume 46 (1993) Issue 10
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QUINOLIDOMICINS A₁, A₂ AND B₁, NOVEL 60-MEMBERED MACROLIDE ANTIBIOTICS

I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

YOICHI HAYAKAWA, MICHIKO MATSUOKA, KAZUO SHIN-YA, HARUO SETO

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 10 Pages 1557-1562

DOI https://doi.org/10.7164/antibiotics.46.1557

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Abstract

Three novel macrolide antibiotics, quinolidomicins A₁, A₂ and B₁, were isolated from the fermentation broth of Micromonospora sp. JY16. Quinolidomicin A₁ inhibited the growth of various tumor cells including multidrug-resistant cells. Quinolidomicin B₁ was similarly cytotoxic, while quinolidomicin A₂ was inactive against these tumor cells.

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