ENDOTHELIN-BINDING INHIBITORS, BE-18257A AND BE-18257B I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

KATSUHISA KOJIRI; MASAKI IHARA; SHIGERU NAKAJIMA; KENJI KAWAMURA; KOHTARO FUNAISHI; MITSUO YANO; HIROYUKI SUDA

doi:10.7164/antibiotics.44.1342

ENDOTHELIN-BINDING INHIBITORS, BE-18257A AND BE-18257B

I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

KATSUHISA KOJIRI, MASAKI IHARA, SHIGERU NAKAJIMA, KENJI KAWAMURA, KOHTARO FUNAISHI, MITSUO YANO, HIROYUKI SUDA

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JOURNAL FREE ACCESS

1991 Volume 44 Issue 12 Pages 1342-1347

DOI https://doi.org/10.7164/antibiotics.44.1342

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Abstract

Two endothelin (ET)-binding inhibitors, BE-18257A and BE-18257B, which antagonized ¹²⁵I-ET-1 binding to a porcine aortic smooth muscle membrane, were isolated from the mycelium of a strain of Streptomyces misakiensis. These binding inhibitors were extracted with methanol from mycelium and purified by HPLC.

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