CYTOTOXIC, FUNGICIDAL NUCLEOSIDES FROM BLUE GREEN ALGAE BELONGING TO THE SCYTONEMATACEAE

JEFFREY B. STEWART; VOLKER BORNEMANN; JIAN Lu CHEN; RICHARD E. MOORE; FAITH R. CAPLAN; HELEN KARUSO; LINDA K. LARSEN; GREGORY M. L. PATTERSON

doi:10.7164/antibiotics.41.1048

JEFFREY B. STEWART, VOLKER BORNEMANN, JIAN Lu CHEN, RICHARD E. MOORE, FAITH R. CAPLAN, HELEN KARUSO, LINDA K. LARSEN, GREGORY M. L. PATTERSON

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JOURNAL FREE ACCESS

1988 Volume 41 Issue 8 Pages 1048-1056

DOI https://doi.org/10.7164/antibiotics.41.1048

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Abstract

Tubercidin, toyocamycin, and the corresponding 5'-α-D-glucopyranose derivatives of the nucleosides are frequently responsible for much of the cytotoxicity and antimycotic activity associated with extracts of cultured cyanophytes belonging to the family Scytonemataceae. The 5'-α-D-glucopyranoses of tubercidin and toyocamycin, for example, are the major cytotoxic and fungicidal nucleosides in Fijian Plectonema radiosum and Hawaiian Tolypothrix tennis, respectively.

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