The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
BIOSYNTHESIS OF KETOMYCIN
YOSHIO TAKEDA, VIVIEN MAK, CHID-CHIN CHANG, CHING-JER CHANG, HEINZ G. FLOSS
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1984 Volume 37 Issue 8 Pages 868-875

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Abstract

The antibiotic ketomycin is formed from shikimic acid via chorismic acid and prephenic acid. Phenylalanine and 2', 5'-dihydrophenylalanine are not intermediates in the biosynthesis. Degradation of ketomycin derived from [1, 6-14Clshikimic acid showed that prephenic acid is converted into ketomycin with stereospecific discrimination between the two enantiotopic edges of the ring, the pro-S-R edge giving rise to the C-2', C-3' side of the cyclohexene ring of ketomycin.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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