Cleidocranial dysplasia is a rare syndrome usually caused by an autosomal dominant gene without gender predilection. This condition is characterized by severe skeletal and dental malformations and underdevelopment, including partial or total absence of unilateral or bilateral clavicles, multiple impacted supernumerary teeth and impacted permanent teeth. In this article, a case of cleidocranial dysplasia of a 25-year-old Taiwanese female is reported. She visited Taichung Veterans General Hospital Department of Dentistry for the treatment of dental caries in March, 2005. Her abnormalities were diagnosed by Oral and Maxillofacial Surgeon, and was later certified by physician of Genetic Consultation and radiologist. Details of the clinical feature, radiographic findings, and management by means of team-work are discussed.