Proliferative verrucous leukoplakia (PVL) was first proposed in 1985 by Hansen et al. It is an aggressive form of idirpathic leukpolakia which has a strong potential for malignant change. PVL has a continuous spectrum of clinical and pathological expression, ranging from homegeneous white patch to squamous cell carcinoma. Initially it appears as hyperkeratosis, then it sperads out and becomes an exophytic, multifocal, pleomorphic verrucous lesion. Finally it changes into squamous cell carcinoma. The clinical behavior of PVL is persistently slow-growing, irreversible and easy recurring. In this study we analyzed 60 cases of PVL that found in Chi-Mei Hospital from July 1992 to June 1997. The mean follow up period is 1.41 years. Analysis of the patients found that (1) males are predominant (59:1) (2) the mean age was 51.7, lower than that in other reports (3) the buccal mucosa was the most commanly affected sites (4) 34% of the patients had malignant changes. These finding were greatly different from those in other reports., In this study the habit of betel guid chewing and smoking (83% of the patients had the habit of betel quid chewing and 95% smoked; 80% had both) may have strong strong influences on the characteristic epidemidogical features of the sample.