This study was scheduled for 2 years. The data presented herein are the results of the first-year study. The purposes of the first-year’s study were to (1) explore the distress, stress, and coping strategies of infertility on the infertile couples, and (2) compare the differences in distress, stress, and coping strategies between wife and husband. Fifty-nine infertile couples answered the study instrument which was developed by the researchers. This 4 parts instrument included Demographic Data, Infertility Questionnaire, Stress Scale, and a Coping Strategies Scale. The results indicated that husbands had significantly less distress than wives. Husbands’ self-esteem was higher than wives’. Husbands’ stress toward infertility examination and treatment was less than wives’. The frequency of increasing the space strategies used by husbands was less than those used by wives. The study results provide valuable information for health care professionals.