In recent years, the prevalence of adolescence obesity has continued to rise rapidly with changing life style. Obesity increases the risk of insulin resistance, diabetes, hypertension, cardiovascular diseases, and nonalcoholic fatty liver. To date, few weight management programs have been implemented on campus. This research is designed to study the college student demographic group. This program involved 30 participants, whose mean age was 16.4 and whose BMI was over 30. Over the course of 10 weeks, participants were given combined dietary, behavioral, and physical-activity interventions. At the beginning of the program, the group showed high prevalence of hypercholesterolemia (46.7%), hypertriglyceridemia (46.7%), glucose intolerance (13.3%), abnormal liver function test (43.3%) and symptoms of depression (46.2%). After 8 weeks, there were significant changes in body weight (-2 kg), serum total cholesterol level (-19.3 mg/dL), and abnormal liver function tests (-20%). The degree of weight loss was probably associated with the improvement of hyperlipidemia and liver function, and those with significant weight loss (＞ 2.5%) tended to have better weight control one year after participating in the program. This research demonstrates that the combined dietary, behavioral, and physical-activity intervention helped to control weight and to improve metabolic abnormalities. It also emphasizes that intervention in adolescent obesity requires a holistic approach. Additional evaluations of long-term effectiveness are recommended.