This descriptive correlation study was to evaluate the job stress, coping behaviors and related factors for psychiatric nurses in eastern Taiwan. 143 nurses, collected from seven psychiatric medical hospitals, were evaluated by ”stress scale”, ”coping scale” and ”social support scale”. The researcher found that nurses perceived medium-degree job stress. The highest stress came from ”incompleteness of personal arrangement”, ”together with family and friends” were the most frequent stressors. The work-related stress was significantly related to tile age, the experience in psychiatric care and nursing care, and the emotion-oriented behaviors, 73.0% of the variance in job stress of nurses can be explained by emotion-oriented coping, experience in psychiatric care and nursing care, and social support. The most often used coping method for these nurses was problem-oriented behaviors. ”Learning experience” was the most frequent coping behaviors. The coping behaviors were significant related to the social support, age tile experience in nursing care, and work-related stress 48% of the variance in coping behaviors of nurses could be explained by personal responses, competency, and social support. This study may help nursing administrators and nurses understand nurse job stress and coping behaviors in eastern Taiwan, which is a basis for designing stress management for nurses and further psychiatric professional development.