Epigastric pain is a common symptom in Taiwan, precipitated by irregular life style, improper dietary habit, and increasing environmental stress in modern society. The typical symptoms include abdominal discomfort, gastric acid regurgitation, and the onset age ranges widely from young to old. Therefore, numerous commercial gastrointestinal medication "Wei san" composed of traditional Chinese medicine (TCM) powder are available easily on the market. However, the regimens and ingredients of these gastrointestinal medication vary from each other, the patients may choose inappropriate products for their individual symptoms. To address this issue, we composed a study to systemically analyze the ingredients of commercially available traditional Chinese gastrointestinal medication to investigate their indication and pharmaceutical mechanism. We collected data from pharmacy and online shopping platform, analyzed the composition and weight proportion in all types of products. Moreover, we also used various key words to query Chinese and western database for extensive and evidenced-based searching guide. A total of 34 products included in our study, and most of them are made from Taiwan, China, and Japan. Taiwan-made products are similar to Er Chen decoction and modified Ping Wei San, and their therapeutic effects are to regulate qi of spleen and stomach, as well as dry dampness to resolve phlegm. The common herbal medicine are Pinellia ternate, Wolfiporia extensa, Citrus reticulata Blanco, Glycyrrhiza uralensis, Mentha haplocaly Brio, Amomum villosum, Eugenia caryophyllata Thunb, Saussurea costus, Atractylodes lancea, Poncirus trifoliata, and Agastache rugosa. Products from China are similar to Xiang Sha Liu Jun Zi Tang which provide therapeutic effects to fortify the spleen and stomach, and their common compositions are Atractylodes macrocephala, Codonopsis pilosula, Wolfiporia extensa, Citrus reticulata Blanco, Pinellia ternate, Glycyrrhiza uralensis, Saussurea costus, Amomum villosum, Cyperus rotundus, and Magnolia officinalis. Japan-made products are similar to Antyu-san, which warm the interior to dissipate cold in the stomach and spleen. Their common used herbal medicine are Cinnamomum cassia, Corydalis yanhusuo, Ostrea rivularis, Foeniculum vulgare, Amomum villosum, Glycyrrhiza uralensis, Alpinia officinarum, Eugenia caryophyllata Thunb, Zingiber officinale, Gentiana scabra, and Mentha haplocaly Brio. As a result, Glycyrrhiza uralensis are the most common prescribed herbal medicine among the products made from three countries. On the other hand, the ingredients of these products are obviously different from their original country. In view point of TCM, epigastric pain might be caused by cold, fire, improper diet, dyspepsia, qi stagnation, or phlegm stagnation. However, commercial gastrointestinal medication may not cover the above disease patterns. In conclusion, the patients may choose unsuitable products without proper pattern diagnosis made by qualified TCM physicians. More clinical trials are warranted to prove their efficacy and safety.