Cancer illness is a family affair. Family plays a very important role in caring for the cancer patients at the end of life. Family support is one of the most crucial determinants for quality of life of dying patients. In addition to the care of cancer patients, nurses need to incorporate their families into nursing caregiving. The purpose of this review was to identify some of the interventions that could soften cancer patients and families' suffering and enhance their healing at the end of life based on literature. Computerized databases MEDLINE, CINAHL, PsycInfo, and Amazon were used to identify the effective interventions. Key words ”dying”, ”family”, ”end-of-life”, ”caring” and ”healing” were used to guide the search of the literature. Some specific interventions that can help families who experiencing the dying process are: being present, enhancing best communication with the family, facilitating the family to say goodbye at the end of life, and responding to the cultural needs of the family. The definition and the practical application of these interventions were discussed. Nurses are in unique position to help families manage their lives when a loved one has terminal cancer illness. Providing end-of-life care during the golden moment is a privilege that should not be taken lightly. Open and trusting communication, physical, psychological, spiritual, social, and emotional support, and respect for families' cultural needs are important for promoting health and facilitating growth at the end of life. It is expected that the literature review can remind nurses at the oncology wards implementing these interventions that can help cancer patients and families at the end of life heal their emotion and promote their health, and go through the golden moment of life.