It is not easy to find an appropriate job for students with intellectual disability. To help students with intellectual disability to get a job successfully in the future, vocational education is therefore very important to students with intellectual disability. This study was conducted with single subject research. The study first adopted the general instruction for three weeks, then cooperative learning was applied for another five weeks, and finally the study went back to the general instruction in the last three weeks. The results showed the scores on vocational education had improved, which implied it was feasible to apply cooperative learning on vocational education for middle school students with intellectual disability. Moreover, the interview showed students with intellectual disability were very glad to cooperate with others under cooperative learning. This study suggested that cooperative learning method was a viable alternative to teach vocational education for students with intellectual disability. Cooperative learning could not only improve the effectiveness of vocational learning, but also help the students to cooperate with others in the future. This study provided a good example of cooperative learning method for special education teachers.