With the economic globalization, the global manufacturing industry faces transformation and upgrade choices, especially in the severe resource constraints, demographic ageing, competitive pressures and the rapid background changes in product demand. How to increase productivity and reduce manufacturing costs and more flexible production methods, became today's global manufacturing's biggest challenges and key factors of success. In addition, the past literature discussed Internet, data, cloud and their impact on industrial and technological development. However, rare studies assessed overall industry 4.0 concept. Therefore, the primary purpose of this study was to explore the application of industry 4.0, information integration and their relationship with new product development performance. This study used SPSS statistical software to analyze data. The sample were collected from high-tech industry in Taiwan and Mainland China. This study used factor analysis, reliability analysis, hierarchical regression analysis, interference analysis during February to March 2016. A total of 206 questionnaires were issued, and eventually 200 were returned. The results of this study are as follows： 1. Industry 4.0 has a significant positive influence on information integration. 2. Information integration has a significant positive impact on new product development performance. 3. Industry 4.0 has a significant positive influence on new product development performance. 4. Information integration has mediating effect on the relationship between industry 4.0 and new product development performance. 5. Product characteristics moderate the relationship between information integration and new product development performance.