Reviewing the global trend, high-tech industry has become the core to improve the economic development in the world. Meanwhile, the products of high-tech industry include the irreplaceable characteristics with high value, the delivery of raw materials from the market, the semi-finished and finished products are required on fright forwarders’ perfect arrangement, the goods can reach the destination with safety in the shortest time, and the high-tech industry can decrease its inventory pressure, reduce losses caused by the loss of high-priced products, reduce inventory and operating costs, and maintain a highly competitive ability in the market. High-tech industry can select the high quality forwarders by the key factors, and forwarders can upgrade a major factor then improve other ones gradually, centralize the limited resource on the most effective factors to increase the competitive advantages in the market. This study took hi-tech industry as a sample and used Decision Making Trial and Evaluation Laboratory (DEMATEL) as the tool to explore the factors influencing the selection of freight forwarders for Taiwan high-tech industry. The result confirms that business should get started from “transport factor” and focus on “business reputation”, “service tangibility” and “reasonable freight rate” to come out the key factors of how to select freight forwarders. Hope that more high-tech enterprises take the results of this study for reference to select forwarders. Freight forwarders can also strengthen weaknesses, and create more win-win cooperation opportunities in the competitive market.