Since 1987 there are rapid changes in the cross-strait, changes includes: economy and others private exchanges are warming relations with China, but the political aspect remain confrontation. The form is uniquely. The highly interactive features not only make the trade rapid development but also make other functional areas further. After 2000, Taiwan's exports growth rate to mainland get higher and higher year after year. Taiwan's total exports depend on China more than fourty percents. China is the largest export market and the biggest trade surplus to Taiwan. After 90s, the regionalism prevails again, in recent years, WTO multilateral negotiations develop very slowly, it puches nations into the regional economic integration. The nations promote a regional trade agreements by signing Free Trade Agreements globally. China-ASEAN Free Trade Area (CAFTA) came into effect in 2010. Taiwan's products will face difficult battles, which can’t compete fairly with other ASEAN members in China market. Taiwan is 17th largest exporter (2009) in the world. If we can’t as soon as enter the regional economic integration globally, especially enter the East Asia regional integration, Taiwanese economy will gradually be marginalized. After taking office, the Ma government has promoted to sign an Economic Cooperation Framework Agreement (ECFA) with China. By the ECFA Taiwan will participate in the regional economic integration to the world and it will stimulate the economic growth in Taiwan. The leaders of China goodwill response to Taiwan, they will to sign the ECFA to Taiwan. The cross-strait government signed ECFA on June 29 this year. It will take effect after waiting for the Legislative’s passage and complete it. The two sides have positive attitude to sign the ECFA, this research discovered that, they are looking forward to other important issues related to current cross-strait economic and trade interaction after the ECFA. However, signing the ECFA successfully not only test the cross-strait relations but also relate to the peaceful development in the future. Certaining, Taiwan should pay attention on the negative effects economiclly and politically. Our government should prevent from hurting and finding the best ways in advance to help the sectors which suffered from ECFA. By doing so, Taiwan should join the East Asian regional economic integration and avoid being marginalized.