Deleuze has played an important role in modern French philosophy. During the 1950s and 1960s, instead of permeating the Hegelianism, he was interested in the history of philosophy, especially Spinoza and Nietzsche’s works. Based on his monograph “Nietzsche and philosophy”, Deleuze developed afterward his own philosophy of difference and published his doctoral thesis: “Difference and Repetition” in 1968. Meanwhile, inspired by May 1968 and Felix Guattari’s work, Deleuze shifted his attention to psychoanalysis and published “Anti- Oedipus” with Guattari in 1972 which challenges every psychological theory. Deleuze’s ambition was to undermine the traditional philosophy and the thought of representation, his interdisciplinary argumentations can be the best affirmation. Therefore, the main purpose of this thesis is to explore the major concept that Deleuze and Guattari creates: desiring-machine. Through his major works at Spinoza, Nietzsche, difference, and desiring-machine, I shall try to clarify some of the more unusual concepts of these works. This thesis includes four parts: first of all, I explore Deleuze’s research in Spinoza and Nietzsche, second, the concepts of difference, repetition and the method of dramatization are the points. Third, I shall elucidate the relationship between desiring -machine and produces connections. Last but not least, the discussion of schizoanalytic theory. Instead of of the Oedipus-dominated psychoanalysis, Deleuze has been advocating schizoanalytic theory. He claims that we should always have the spirit of revolution to pursue the liberty and choose “nomad”.