(1)The Thermosensitive Hydrogels with high loading Hydroxyapatite of Rheological studies and Osteoporosis Application for Evaluation In this research, we used vortex mixer to blend thermosensitive polymer (mPEG-PLGA) which is synthesized by ring-opening polymerization and hydroxyapatite by chemical co-precipitation to get complex of thermosensitive injectable hydrogel and evaluate the application of osteoporosis. Hydroxyapatite is one of the widely used materials that interfaces with bone for clinical application as a filler in dentistry and orthopedic for decades due to its highly biocompatibility. The rheological behavior of the thermosensitive mPEG-PLGA hydrogels could be tailored by incorporating the hydroxyapatite with different particle sizes into the hydrogel. The experimental results, after ball milling the treated hydroxyl apatite more may be added to increase the amount of 70%, and maintaining appropriate gelling temperature. Furthermore, the adverse effect of acid release from gel degradation was overcome by utilizing hydroxyapatite, and the gel degradation rate was also reduced. The cell experiments were hydrogel materials Cytotoxicity assays, the results show that by adding hydroxylapatite (50%) can effectively improve the hydrogel materials biocompatibility. Finally, in animal experiments will mPEG-PLGA / HA composite bone cement injection chamber at the femoral osteoporosis in mice to explore the effectiveness of the treatment of osteoporosis. The results show: injection thermosensitive complex hydrogels can reach a certain repair treatment, and experiments were also added specialized treatment of bone loose of the drug Alendronate or TXAS inhibitors, due to the addition of drug concentration is too low, the effect is no longer significant improvement. (2)Preparation,Characterization and Applocation of Electroactive Hydrogel through UV-curing Technique In this study, the UV light polymerization Preparation of methyl 2-hydroxyethyl methacrylate (HEMA) and methyl allylamine (DMA) copolymerized hydrogel, wherein the incorporation of the aniline trimer of electroactive polymer (ACAT) formed with electroactive copolymer hydrogel Poly (HEMA-co-DMA-co-ACAT), and 2,4,6-Trimethylbenzoyl Diphenyl phosphine Oxide (TPO) as a photoinitiator and Ethylene dimethacrylate (EDMA) as the cross-linking agent, and CV verify its electroactive. In addition, to avoid incorporation (ACAT) will dye dissolution phenomena, thus adding methacrylic acid (MAA) monomer having -COOH functional end groups with (ACAT) NH2 terminal functional groups to form chemical bonds, by FT-IR proved to be a successful bond, while the dissolution test also can be verified, the copolymer hydrogel having a chemical bonding of Poly (HEMA-co-DMA-co-MAA-co-ACAT) is not dissolution phenomenon. Due to UV light polymerization method preparation hydrogel as a thin film type, thickness and nature of contact lenses similar, Therefore, depending on the nature of the contact lenses, measured its associated properties such as: water content light transmittance oxygen permeability, material toxicity and so on. The experimental results and comparison of commercially available contact lenses, and the nature of commercially contact lenses have the same safety and effectiveness.