Abstract The purpose of this study is to explore the actual condition of well-being perception and self-efficacy, as well as to analyze the relationship between well-being perception and self-efficacy of the public senior high school students in Taoyuan County. The study was conducted by means of questionnaire surveys. The researcher compiled the questionnaires based on relevant literature, the opinions of educational experts and senior high school teachers. “The Questionnaire for Well-Being Perception and Self-Efficacy of the Senior High School Students” was used as a research tool for the study. The participants are the senior high school students in Taoyuan County. Among the 938 questionnaires, all of which are valid. The statistical procedures used in this research are mean, t-test, one-way ANOVA, Pearson product-moment correlation, and Canonical correlation. The research obtained conclusions are as following: 1. The well-being perception of the senior high school students is above the average, among which, “allowance” gets the highest score, and “healthy condition” gets the lowest one. 2. The self-efficacy of the senior high school students is above the average, among which, “relationship” gets the highest score; the scores of “physical condition” as well as “academic achievements” are under the average. 3. The students with different backgrounds have significant difference in well-being perception: the junior are happier than the freshpersons and the students studying in social studies are happier than the freshpersons. 4. The students with different backgrounds have significant difference in self-efficacy: the self-efficacy of boys is superior than girls’; the self-efficacy of the student with a boyfriend or a girlfriend is better than the one without; the junior have better self-efficacy than the freshpersons. 5. There are four canonical factors between the dimensions of well-being perception and self-efficacy. 6. The well-being perception has a significant high effect on self-efficacy. According to the findings above, suggestions are offered to educational administrations, schools, teachers, parents and future researchers. Key words: self-efficacy, well-being perception