Due to rapid economic development in Taiwan, intensive population centered on city leading to the building fires rate is much higher compared to other fire types. Generally, lack of escape knowledge and fire safety drills, often result in significant loss of life and property. The toxic gases and smoke produced in fire combustion is the major threat of terrible fire that hindered personnel to escape from fire and caused heavy casualties. Therefore the fire safety equipment and indoor decoration materials must be included in the fire safety planning of building construction in order to avoid or minimize the occurrence of similar disasters. This thesis choses the Taoyuan SIJI hotel case for fire research. Using FDS simulation software to explore fire scene conditions, and restore the temperature, gas layer height, C O concentration and evacuation time. Then change various parameters to analyze the changes of fire field and simulate the physical phenomena of the fire by using computer simulation, especially changes in the amount of inflammables, partition materials, sprinkler equipment, heat release rate and other parameters. The simulation results might be helpful to increase the chance for staff escape at the initial stage of fire and even put out the fire timely to reduce casualties.