Background: Have already known the SLE(Systemic lupus erythematosus) can bring chronic inflammation influence to mankind's physiology the whole organ system. What it was a very typical autoimmune disease, included to change more prepares behind indetermination. In Taiwan, announce according to the health welfare department. Department of Statistics: National health insurance medical treatment statisticses in Year 100 of the Republic of China 20 years old above become adult SLE prevalence is each 100,000 people's out-patient service to contain 14121 people. SLE in common use system erythema the lupus is international clinical cooperation set of/American rheumatism learn of valuation method to indicate the disease severity and organ harm degree. Although still predicting and preparing a rear method very strongly now, must tracking time is long, too slow to be of help in a crisis. The last few years of research has been already pointed out: The inflammation factor(for example CRP, ESR, and IgG...etc.) that SLE produces is playing the course of illness of disease and patient to get into an intensive care unit result important role, this text research is mainly to inquire into inflammation factor IgG and ESR face the influence on patient's everyone of advanced case SLE. Methods: This research aims at to get into for 2008-2012 years certain win the advanced case SLE of the intensive care unit in the area medical center .The patient add up to 448 and after expeling a variety of situations, accept a case to add up to 126.The set(Control Group and Experimental Group) that carries on the cent by the inflammation factor-IgG and the ESR density height then is divided into 3 sets by IgG density height; The same are also divided into 2 sets by ESR density. The examination value data(bio-chemical, the whole bloodses count, the leukocyte classification count etc.), patient of above each difference and patient gets into cause of disease and treatment of intensive care unit day count; The serious degree score(APACH II), the use breather number and the SLE disease movable degree grade point(SLEDAI) compares mutually. Statistics the way of the software package by SPSS(Statistical Package for Social Science)12.0 versions to analytical statistics. Use of statistical method containment: Student's t test, Pearson's Chi-square test or Fisher's exact test, the Kruskal-Wallis Test or Jonckheere-Terpstra test, Logistic regression analyze, this research death statistics analysis adopts the single variable (univariate logistic regression) or change more. Conclusion: Lungs disease is occupies two group of patients to enter the intensive care unit maximum proportion (48.4%); Mortality rate in two groups of comparisons and not remarkable difference (P=0.483).IgG and ESR enter the ICU various aspects relatedness and the comparison regarding the critically ill SLE patients may discover: Can the factor be in disguised form more than by the ESR influence IgG, but signifies IgG not to be unimportant by no means, but the reason possibly is accepts a case the number only to be restricted in the sole medicine center also to accept a case the patient who the condition is first time enters the intensive care unit, perhaps the female community number only then 126, affect the control group and the experimental group in the mortality rate, the biochemistry examination, the respirator use, APACH II And SLEDAI index and so on results.IgG and ESR are by no means the SLE patient's specificity inflammation factors, should have other concealment factor perhaps the patient comes under the antibiotic strain infection influence in the intensive care unit, therefore during the complex mechanism, must treat the further research.